TRAINING PROGRAM IN DEVELOPMENTAL GENETICS

这项提案要求支持纽约大学的发育遗传学(DG)项目。这一DG培训计划联合了纽约大学系统内两个不同实体的教师，纽约大学生物系和纽约大学医学中心发育遗传学计划。DG计划的目标是加强和拓宽给予对生物学学科有浓厚兴趣的学生的研究视角。这一成功在很大程度上是由于实现了控制进化中看似分离的生物体发育的分子机制的保守程度。发育遗传学对理解疾病基础的意义在于它的出现。该计划的一个长期目标是创造一个互动的环境，将发育遗传学基本原理的研究与对疾病影响的分子机制的理解结合起来。由于发育遗传学培训地点靠近充满活力的医疗中心，这一目标将得到加强。该计划目前由来自纽约大学医学中心Skirball研究所和纽约大学生物系的14名杰出教员组成，他们使用分子、细胞和遗传学方法研究各种生物(果蝇、线虫、拟南芥、老鼠、鸡、斑马鱼)的胚胎发育。这一新计划得到了纽约大学医学中心和纽约大学生物系的大力支持，包括最先进的设施和各级一流教师的招聘。纽约大学医学中心萨克勒研究生院和纽约大学生物系的开放研究生项目积极招生，吸引了包括未被充分代表的少数族裔学生在内的高素质研究生。8个研究生培训职位(博士和医学博士/博士)都是被要求的。发育遗传学培训计划的具体目标是：1)在互动和大学研究环境中提供严格的发育遗传学培训。2)增加申请和参加该方案的高素质学生的数量，包括积极招募代表不足的少数族裔。3)在培训的各个阶段为学生提供指导。这包括公开讨论与科学方法有关的问题和对结果的解释，以及提高对与科学研究有关的伦理问题的认识。4)就发育遗传学的培训如何促进医学、基因技术、基因组研究和进化等许多不同领域的进步提供广阔的视角。这包括关于研究生职业选择的详细信息和讨论。5)提供一个行政结构，支持同一所大学内两个实体(纽约大学医学中心Skirball研究所和纽约大学生物系)的协调。

This proposal requests support for a Developmental Genetics (DG) Program at New York University. This DG Training Program joins faculty from two different entities within the NYU system, the Department of Biology at NYU and the Developmental Genetics Program at NYU Medical Center. The goal of the DG Program is to enhance and broaden the research perspective given to students with strong interest in disciplines in biology. This success is largely due to the realization of the degree of conservation in the molecular mechanism that control development in evolutionary seemingly separate organisms. The implications of developmental genetics for the understanding of the basis of disease are its emergence. A long term goal of this program is to seed an interactive environment that combines research in the basic principles of developmental genetics with the understanding of the molecular mechanisms that are affected by disease. This goal will be enhanced by the proximity of the developmental genetics training site to a vibrant Medical Center. The Program consists presently of a group of 14 outstanding faculty from the Skirball Institute at NYU Medical Center and the Department of Biology, NYU who are using molecular, cellular and genetic approaches to study embryonic development in a variety of organisms (Drosophila, C. elegans, Arabidopsis, Mouse, chicken, zebrafish). This new program receives strong support from the NYU Medical Center and the Department of Biology at NYU in terms of state of the art facilities and recruitment of first-rate faculty at all levels. Aggressive recruitment efforts by the open graduate programs at the Sackler School of Graduate studies at NYU Medical Center and the department of Biology at NYU has lead to the attraction of high caliber graduate students including under-represented minority students. Eight positions for graduate student training (Ph.D. and MD/Ph.D.) are requested. The specific goals of the training program in Developmental Genetics are: 1) To provide rigorous training in developmental genetics within an interactive and collegial research environment. 2) To increase the number of high caliber students that apply to and participate in the program including active recruitment of under- represented minorities. 3) To provide students with guidance during all phases of their training. This includes the open discussion of the problems associated with the scientific method and the interpretation of results as well as the building of awareness towards the ethical problems associated with scientific research. 4) To provide a broad perspective on how training in Developmental Genetics can contribute to the progress in many different areas such as medicine, gene technology, genome research and evolution. This includes detailed information and discussion of post graduate career choices. 5) To provide an administrative structure that supports the coordination of two entities (Skirball Institute at NYU Medical Center and Department of Biology at NYU) within the same university.