TRAINING IN TRAUMA AND SEPSIS RESEARCH

创伤和脓毒症研究培训

• 批准号: 6605028
• 负责人: TIMOTHY R BILLIAR
• 金额: $ 23.08万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6605028
• 关键词: TRAINING; TRAUMA; SEPSIS; RESEARCH

This postdoctoral training program proposal is designed to train fellows, principally surgeons, for a period of two-to-three years each, in basic science research relevant to trauma and sepsis. Funds to support a total of five positions each year (two new fellows each year, two second year positions, and one third-year) are requested. The overall research focus of the trainees is the molecular biology of the inflammatory response to injury. Three areas of research have been targeted: I) The molecular biology of hemorrhagic and traumatic shock; II) The regulation and function of nitric oxide in sepsis and trauma; and III) Mechanisms of immunoregulation in surgical patients. These areas coincide with current extramural research grants on which the faculty collaborate. The research plans are superb vehicles for training because they ask broad questions on which precise, well-targeted individual research training efforts can be staged. The faculty is highly qualified, and all principle trainers have extramural research support and much training experience. Upon completion of the training program the fellow will understand how to design, carry out, and complete experiments to answer discrete biological questions derived from trauma victims and septic patients. The fellow will thus be trained, not simply in the sophisticated laboratory methodology in molecular biology, biochemistry, and cellular immunology, but also in the though processes to apply to future experimental problems. All trainees will have the opportunity to take formal academic courses offered by the basic science departments of the University of Pittsburgh and some will complete PhDs in the basic science departments. Most training will take place in the laboratories of the principle trainers who are all extramural grant-funded senior scientists in the areas of molecular biology, biochemistry, immunology, and cell biology, using a carefully though-out and well-proven modification of the master/apprentice system. The central training technique combines weekly one-on-one meetings between the apprentice and the trainer plus hour- long research training seminars twice weekly at which supervision subcommittees of four or five trainers, whose special skills supplement the friendly collaborative research and training simultaneously. The individual fellows choose a principle trainer and the Executive Training Committee tailors a fellowship supervising committee of faculty co- trainers to provide expert training necessary to supplement the talents of the principal trainer. Affirmative action recruitment efforts have already been very successful, and will continue; the training facilities can serve more fellows than will be funded by this training proposal. All the training can be carried out in the more than 50,000 square feet of fully equipped laboratory space available.

该博士后培训计划旨在培训研究员，主要是外科医生，每个为期两到三年，与创伤和败血症相关的基础科学研究。要求提供资金，每年支助总共五个职位（每年两个新的研究员，两个第二年的职位，一个第三年的职位）。学员的总体研究重点是损伤炎症反应的分子生物学。有三个研究领域是有针对性的：一）出血性和创伤性休克的分子生物学;二）一氧化氮在脓毒症和创伤中的调节和功能;三）手术患者的免疫调节机制。这些领域与教师合作的当前校外研究赠款相吻合。研究计划是培训的极好工具，因为它们提出了广泛的问题，可以在这些问题上进行精确的、有针对性的个人研究培训工作。教师是高素质的，所有的主要培训师都有校外研究支持和丰富的培训经验。完成培训计划后，研究员将了解如何设计，实施和完成实验，以回答来自创伤受害者和脓毒症患者的离散生物学问题。因此，该研究员将接受培训，不仅包括分子生物学、生物化学和细胞免疫学领域复杂的实验室方法，还包括应用于未来实验问题的过程。所有受训人员都将有机会参加匹兹堡大学基础科学系提供的正式学术课程，有些人将在基础科学系完成博士学位。大多数培训将在主要培训员的实验室进行，这些培训员都是分子生物学、生物化学、免疫学和细胞生物学领域的校外赠款资助的资深科学家，采用经过深思熟虑和充分证明的师傅/学徒制度的修改。中心培训技术结合了学徒和培训师之间每周一对一的会议，以及每周两次长达一小时的研究培训研讨会，在研讨会上，由四到五名培训师组成的监督小组委员会，他们的特殊技能同时补充了友好的合作研究和培训。研究员个人选择一名主要培训师，行政培训委员会专门设立一个由教师共同培训师组成的研究金监督委员会，提供必要的专家培训，以补充主要培训师的才能。平等权利行动征聘工作已经非常成功，并将继续下去;培训设施可以为更多的研究员提供服务，而不是由本培训提案供资。所有的培训都可以在超过50，000平方英尺的设备齐全的实验室空间内进行。