Biofilm-Resistant Dental Unit Water Lines

描述：拟议的研究将调查修改牙科 具有新颖但廉价的用于单重态的光敏剂的单位水线 氧气利用氧化还原法将水中的溶解氧转化为单线态氧， 低功率可见光。正常情况下进入半透明 室内光线充足。单线态氧很久以前就被发现了 作为一种有效的消毒剂。第一阶段研究将验证聚氨酯 最常用于牙科综合治疗台水管线的酯管可 用光敏剂进行化学修饰。第二种形式的管道，基于 在PVC上，也将使用相同的化学物质生产，以增加 一个有用的产品的可能性。化学过程的影响， 单线态氧对管路材料的影响以及所用增塑剂的影响 将检查管路中的光敏剂。照明 将研究光敏剂的要求， 横截面和横向。由于如此少量的光 需要时，半透明管可用于将光分配到 牙科综合治疗台的阴影区域。在每个阶段，管路将接受 污染的水，并评估生物膜的发展。

DESCRIPTION: The proposed research will investigate the modification of Dental unit water lines with a novel yet inexpensive photosensitizer for singlet oxygen. The dissolved oxygen in the water is promoted to singlet oxygen using low power visible light. The light that normally passes into the translucent tubing from room light should be sufficient. Singlet oxygen has long been known as a potent disinfectant. This Phase I research will verify that polyurethane ester tubing, that which is most commonly used for Dental unit water lines, may be chemically modified with the photosensitizer. A second form of tubing, based on PVC, also will be produced using the same chemistry to increase the probability of a useful product. The effects of the chemical process and singlet oxygen on the tubing material and the effects of the plasticizers used in the tubing on the photosensitizer will be examined. The lighting requirements for the photosensitizer will be investigated both cross-sectionally and laterally. Since such a small amount of light is required, the translucent tubing may be used to distribute the light into shaded regions of the Dental unit. At each stage, tubing will be subjected to contaminated water and evaluated for the development of biofilm.