West Coast AIDS and Cancer Specimen Bank Consortium

这项申请代表了艾滋病病毒库（AMB）的更新，现在 被称为艾滋病和癌症标本库（ACSB），该计划最初由 1994年，美国国家癌症研究所（NCI）。自从这件事开始以来， 计划，五个参与机构已成功举办了一个 国家艾滋病和癌症标本库。ACSB包含43个类别 恶性肿瘤标本和对照标本与临床相关 信息. UCSF-ACSB的具体目标是：1）制定 西海岸艾滋病和癌症标本库（ACSB） 以加州大学旧金山分校弗朗西斯科（UCSF）为中心; 2）扩大 加强UCSF-ACSB的功能; 3）积极参与 国家ACSB，并满足NCI要求继续ACSB参与。 在第一个具体目标中，USC和UCSD将被添加到原始的UCSF中 财团南加州大学的Parkash Gill博士将监督从 位于洛杉矶的中央基地布莱恩·赫恩迪尔博士，直到最近加州大学旧金山分校 ACSB病理学家将在圣地亚哥启动一个新的ACSB站点。加州大学旧金山分校的附属医院，包括SFGH，拉古纳本田，VAMC和山。锡安必 继续为弗朗西斯科ACSB核心提供锚。这些位于弗朗西斯科的网站 超过200，000个标本被储存起来，在未来的五年里， 不仅作为一个有用的资源，而且作为一个协调的网络， 标本作为科学界的研究问题不断发展。 在第二个具体目标中，西海岸ACSB将与现有的 样本库合并数据库中的数据，以增加对 相关的标本已经存在。具体来说，UCSF艾滋病标本 自1983年以来，该银行已将173，000份与艾滋病有关的样本提供给 ACSB。关于积极贡献者的信息将作为一个网络， 获得新的标本。西海岸ACSB和一个大型 现有的样本银行是未来计划的“虚拟”银行的模型 通过ACSB中央操作和数据协调进行ACSB开发 中心（CODCC）将于明年成立。 最后，西海岸ACSB已将两个主要的财团网站合并， 南加州，响应ACSB的总体目标 这是由RFA。西海岸与美国 麦格拉思博士将向与其他资助的ACSB研究中心的联合体提供保证？S 继续参与国家ACSB的全面领导。

This application represents a renewal of the AIDS Malignancy Bank (AMB), now known as the AIDS and Cancer Specimen Bank (ACSB), program initially funded by the National Cancer Institute (NCI) in 1994. Since the initiation of this program, five participating institutions have successfully organized a national AIDS and Cancer Specimen Bank. The ACSB contains 43 categories of malignancy specimens and controls with specimen associated clinical information. The UCSF-ACSB specific aims for this proposal are: 1) to develop a cohesive West Coast based AIDS and Cancer Specimen Bank (ACSB) consortium centered at the University of California, San Francisco (UCSF); 2) to expand and enhance the UCSF-ACSB function; and 3) to actively participate in the national ACSB and fulfill NCI requirements for continued ACSB participation. In the first specific aim, USC and UCSD will be added to the original UCSF consortium. Dr. Parkash Gill at USC will oversee sample acquisition from a centralized base in Los Angeles. Dr. Brian Herndier, until recently the UCSF based ACSB pathologist will initiate a new ACSB site in San Diego. UCSF?s affiliated hospitals including SFGH, Laguna Honda, VAMC, and Mt. Zion will continue to anchor the San Francisco ACSB core. These San Francisco sites have more than 200,000 specimens banked and during the next five years will serve not only as a useful resource but as a coordinated network for obtaining new specimens as research questions in the scientific community evolve. In the second specific aim, the West Coast ACSB will work with existing specimen banks to merge data from their databases so as to increase access to relevant specimens already in existence. Specifically, the UCSF-AIDS Specimen Bank has made available 173,000 AIDS related specimens obtained since 1983 to the ACSB. Information on active contributors will serve as a network for obtaining new specimens. This interface between West Coast ACSB and a large existing specimen bank is a model for "virtual" banking planned for future ACSB development through the ACSB Central Operations and Data Coordinating Center (CODCC) to be established next year. Finally, the West Coast ACSB has incorporated two major consortium sites in southern California that are responsive to the overall objectives of the ACSB made by this RFA. The coordinated interaction between this West Coast consortium with other funded ACSB sites will be assured by Dr. McGrath?s continued participation in the overall leadership of the national ACSB.