Envelope glycoprotein determinants underlying cytopathicity of CCR5-restricted human immunodeficiency virus type 1

CCR5 限制性人类免疫缺陷病毒 1 型细胞病变的包膜糖蛋白决定因素

• 批准号: nhmrc : 543103
• 负责人: Prof Paul Gorry
• 金额: $ 28.58万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/envelope-glycoprotein-determinants-type-1/115874
• 关键词: Envelope; glycoprotein; determinants; underlying; cytopathicity

HIV weakens the immune system causing AIDS, but the mechanism by which HIV does this are poorly understood. This proposal aims to define these mechanisms. We expect that HIV evolves in infected people, becoming better able to infect and kill cells of the immune system, and that this results from specific genetic changes in the virus. This study will contribute to a greater understanding of how HIV causes AIDS, which is necessary for the development of new drugs to treat HIV infection.

艾滋病毒削弱免疫系统，导致艾滋病，但艾滋病毒这样做的机制知之甚少。本提案旨在界定这些机制。我们预计，艾滋病毒在感染者体内进化，变得更能够感染和杀死免疫系统的细胞，这是病毒中特定基因变化的结果。这项研究将有助于更好地了解艾滋病毒如何导致艾滋病，这对于开发治疗艾滋病毒感染的新药是必要的。