IMMUNOLOGY AND IMMUNOTHERAPY

描述：(申请者描述)该计划的总体目标是 免疫学和免疫疗法是了解免疫的基本要素 癌细胞逃避免疫系统的机制使得新的 可以制定干预策略来减轻癌症负担。这是 通过促进协作和鼓励 对免疫力和免疫力之间关系的广泛调查 癌症。科罗拉多大学癌症中心领导层重组了 1998年和1999年癌症中心的结构，以更好地促进 翻译研究和合作，并加强对癌症的关注。 成人临床肿瘤学的老年黑色素瘤和神经肿瘤学焦点组 与免疫学项目相结合，形成了新的免疫学和 免疫治疗计划。因此，免疫学和 免疫疗法现在有35名正式成员，在 细胞和结构生物学、皮肤科、免疫学、医学系、 神经学、病理学、儿科学、放射学、放射肿瘤学和外科。 该小组包括免疫学系主任和三名成员 美国国家科学院院士。计划成员拥有近1200万美元 每年从90多笔赠款中获得的直接费用。自上次审查以来， 来自所有机构的赠款都有所增加，特别是NCI， 以及美国国立卫生研究院。计划成员贡献了250种出版物，约40种 涉及与两个或更多癌症中心成员合作的百分比 作者。骨髓移植、黑色素瘤计划项目倡议 治疗，控制细胞死亡和分化。 招聘对人类肿瘤免疫学有兴趣的新教员和 免疫疗法已经启动。癌症中心提供种子资金给 支持可能演变为计划项目应用程序的试点项目。 乳腺癌、脑癌和皮肤癌免疫疗法的临床试验正在进行中， 关于肺癌治疗的临床前研究也很有希望。

Description: (Applicant's Description) The overall goal of the Program in Immunology and Immunotherapy is to understand the basic elements of immunity and the mechanisms by which cancer cells evade the immune system so that new intervention strategies can be developed to reduce the cancer burden. This is accomplished programmatically by fostering collaborations and encouraging a broad range of investigations into the connections between immunity and cancer. The University of Colorado Cancer Center leadership reorganized the structure of the Cancer Center in 1998 and 1999 in order to better promote translational research and collaborations, and to strengthen the cancer focus. The old Melanoma and Neuro-oncology focus groups from Adult Clinical Oncology were combined with the Immunology Program to form the new Immunology and Immunotherapy Program. As a consequence, the Program in Immunology and Immunotherapy now has 35 full members holding primary appointments in the Departments of Cell and Structural Biology, Dermatology, Immunology, Medicine, Neurology, Pathology, Pediatrics, Radiology, Radiation Oncology, and Surgery. The group includes the Chair of the Department of Immunology and three members of the National Academy of Sciences. Program members have nearly $12 million in annual direct costs from more than ninety grants. Since the last review, there has been an increase in grants from all agencies, especially the NCI, and NIH. Program members contributed 250 publications, approximately 40 percent involving collaborations with two or more Cancer Center members as authors. Program project initiatives in bone marrow transplantation, melanoma therapy, and control of cell death and differentiation were undertaken. Recruitment of new faculty with interests in human tumor immunology and immunotherapy has been initiated. The Cancer Center provided seed funding to support pilot projects that might evolve into a program project application. Clinical trials in breast, brain, and skin cancer immunotherapy are underway, and promising pre-clinical studies on lung cancer treatment have been made.