LARYNGEAL FUNCTION IN RESPIRATION

在过去的五年里，首席调查员(PI)专注于 他对上呼吸道呼吸功能的关注。正在进行中 研究试图阐明调节呼吸的因素-- 上呼吸道肌肉的相关活动。此外，目前的工作 旨在确定上呼吸道肌肉在发病机制中的作用 临床上的睡眠障碍，阻塞性睡眠呼吸暂停。 UTMB加尔维斯顿的肺科为PI提供了 在三个方面寻求这些问题的答案的独特机会 重要领域：动物研究和临床研究 清醒和睡眠。在接下来的五年里，PI寻求 发展HIS动物、睡眠与呼吸实验室临床控制 成为一个综合的网络，用于生理和心理研究 上呼吸道功能的病理生理学方面。另外两个相关的 未来五年的目标是：1)加强合作关系 与其他对上呼吸道功能有主要兴趣的研究人员 以及2)发展基础神经生理学的专业知识，这将是 用于研究上呼吸道的神经运动控制。 除了正在进行的关于阻塞性睡眠发病机制的工作外 呼吸暂停，未来五年的具体研究将集中在 喉部在调节人类呼吸方面的作用。新的 我们实验室开发的技术使肌电图仪 常规从以前无法访问的3个获取的录音 喉部肌肉：甲状旁肌、颧骨肌和喉后肌 环状突起。对此应用程序的支持将允许该应用程序 这些技术，以确定控制的因素 这些喉部固有肌肉的呼吸相关活动。 肌电记录与测量结果的相关性 喉部呼吸道阻力和声带位置将用于 确定1)控制的生理和病理生理因素 喉内肌的呼吸相关活动，2) 喉内在肌活动变化的净效应 喉部功能。

Over the past five years, the principal investigator (PI) has focused his attention on the respiratory function of the upper airway. Ongoing research seeks to elucidate the factors which modulate the respiratory- related activity of upper airway muscles. In addition, current work seeks to determine the role of upper airway muscles in the pathogenesis of the clinical sleep disorder, obstructive sleep apnea. The Pulmonary Division at UTMB Galveston has provided the PI with the unique opportunity to pursue the answers to these questions in three important areas: animal research, and clinical research during both wakefulness and sleep. Over the next five years, the PI seeks to develop his Animal, Sleep and Clinical Control of Breathing Laboratories into an integrated network for the investigation of physiologic and pathophysiologic aspects of upper airway function. Two other related goals over the next five years are 1) to strengthen collaborative ties with other investigators with primary interests in upper airway function and 2) to develop the expertise in basic neurophysiology which will be applied to studying neuromotor control of the upper airway. In addition to ongoing work on the pathogenesis of obstructive sleep apnea, specific research over the next five years will focus on the role of the larynx in the regulation of respiration in humans. New techniques developed in our laboratory allow electromyographic recordings to be routinely obtained from 3 previously inaccessible laryngeal muscles: the thyroarytenoid, arytenoideus and posterior cricoarytenoid. Support of this application will allow the application of these techniques to determine the factors which control the respiratory-related activity of these intrinsic laryngeal muscles. Correlation of the electromyographic recordings with measurements of laryngeal airway resistance and vocal cord position will be used to determine 1) the physiologic and pathophysiologic factors which control the respiratory-related activity of intrinsic laryngeal muscles, and 2) the net effect of changes in intrinsic laryngeal muscle activity on laryngeal function.