PATHOPHYSIOLOGY AND MOLECULAR GENETIC BASIS OF GOUTY DIATHESIS

痛风素质的病理生理学和分子遗传学基础

• 批准号: 6567650
• 负责人: KHASHAYAR SAKHAEE
• 金额: $ 32.14万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6567650
• 关键词: acid base balance; ammonium compounds; clinical research; genetic disorder; gout; human data; insulin sensitivity /resistance; pathologic process; phosphates; syndrome

The overall goal of this project is to elucidate pathophysiology and molecular genetic basis for gouty diathesis (stone formation associated with gout). Aim 1, concerned with pathophysiology, will test the hypothesis that a defective ammonium production may be uncovered by controlling acid intake and imposing phosphate restriction, and that in the acquired form of gouty diathesis, an insulin resistance is responsible for undue urinary acidity and other biochemical features of gouty diathesis. Aim 2 is directed at identifying the molecular defect in the "primary" form of the syndrome.

该项目的总体目标是阐明病理生理学， 痛风素质的分子遗传学基础（结石形成相关 痛风）。 目标1，与病理生理学有关，将测试 假设有缺陷的铵生产可能被发现， 控制酸的摄入和限制磷酸盐的摄入， 痛风素质的获得性形式，胰岛素抵抗， 负责不适当的尿液酸度和其他生化特征， 痛风素质 目标2是针对识别分子缺陷 在综合症的“初级”形式中。