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PATHOPHYSIOLOGY AND MOLECULAR GENETIC BASIS OF GOUTY DIATHESIS

PATHOPHYSIOLOGY AND MOLECULAR GENETIC BASIS OF GOUTY DIATHESIS
痛风素质的病理生理学和分子遗传学基础
批准号:
6567650
负责人:
KHASHAYAR SAKHAEE
金额:
$32.14万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-12-01 至 2002-11-30

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中文摘要
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英文摘要
The overall goal of this project is to elucidate pathophysiology and molecular genetic basis for gouty diathesis (stone formation associated with gout). Aim 1, concerned with pathophysiology, will test the hypothesis that a defective ammonium production may be uncovered by controlling acid intake and imposing phosphate restriction, and that in the acquired form of gouty diathesis, an insulin resistance is responsible for undue urinary acidity and other biochemical features of gouty diathesis. Aim 2 is directed at identifying the molecular defect in the "primary" form of the syndrome.
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Pathogenesis of Idiopathic Uric Acid Nephrolithiasis: The Role of Renal Lipotoxic
  • 批准号:
    7812212
  • 项目类别:
  • 资助金额:
    $37.3万
  • 财政年份:
    2009
  • 负责人:
    KHASHAYAR SAKHAEE
  • 依托单位:
Pathogenesis of Idiopathic Uric Acid Nephrolithiasis: The Role of Renal Lipotoxic
  • 批准号:
    8072745
  • 项目类别:
  • 资助金额:
    $33.47万
  • 财政年份:
    2009
  • 负责人:
    KHASHAYAR SAKHAEE
  • 依托单位:
Pathogenesis of Idiopathic Uric Acid Nephrolithiasis and Renal Lipotoxicity
  • 批准号:
    8271447
  • 项目类别:
  • 资助金额:
    $33.47万
  • 财政年份:
    2009
  • 负责人:
    KHASHAYAR SAKHAEE
  • 依托单位:
Pathogenesis of Idiopathic Uric Acid Nephrolithiasis: The Role of Renal Lipotoxic
  • 批准号:
    7653921
  • 项目类别:
  • 资助金额:
    $37.68万
  • 财政年份:
    2009
  • 负责人:
    KHASHAYAR SAKHAEE
  • 依托单位:
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