EFFECT OF POTASSIUM ALKALI ON BONE LOSS AND STONE RISK INDUCED BY ATKINS' DIET

碱钾对阿特金斯饮食引起的骨质流失和结石风险的影响

• 批准号: 7606335
• 负责人: KHASHAYAR SAKHAEE
• 金额: $ 1.33万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606335
• 关键词: Acids; Adopted; Alkalies; Animal Model; Animals; Atkins Diet; Calcium; Calculi; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Diet; Fatty acid glycerol esters; Funding; Goals; Grant; Institution; Intake; Intestines; Kidney Calculi; Potassium; Proteins; Research; Research Personnel; Resources; Risk; Source; Testing; United States National Institutes of Health; absorption; bone loss; bone metabolism; potassium citrate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to continue efforts toward identifying potential deleterious effects of high animal protein diet on bone metabolism and kidney stone formation, and ascertain the value of potassium alkali as a countermeasure. The overall hypotheses to be tested are: 1) a high animal protein intake confers an acid load, which then causes bone loss and increases stone-forming risk, 2) potassium citrate corrects these deleterious effects by "neutralizing" the acid load, 3) intestinal calcium absorption is enhanced by potassium alkali in the setting of an acid load. The model for animal protein excess adopted in this effort is the Atkins' diet, where in the restriction of carbohydrates and liberal intake of fat leads to an exaggerated intake of animal proteins that confers a marked acid load.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目的目标是继续努力确定高动物蛋白饮食对骨代谢和肾结石形成的潜在有害影响，并确定钾碱作为对策的价值。 待检验的总体假设为： 1)高动物蛋白摄入量会产生酸负荷，从而导致骨质流失并增加结石形成的风险， 2)柠檬酸钾通过“中和”酸负荷来纠正这些有害作用， 3)在酸负荷的情况下，钾碱可增强肠钙吸收。 在这一努力中采用的动物蛋白质过量的模型是阿特金斯饮食，其中限制碳水化合物和自由摄入脂肪导致动物蛋白质的过度摄入，从而产生显著的酸负荷。