EFFECT OF POTASSIUM ALKALI ON BONE LOSS AND STONE RISK INDUCED BY ATKINS' DIET

碱钾对阿特金斯饮食引起的骨质流失和结石风险的影响

• 批准号: 7606335
• 负责人: KHASHAYAR SAKHAEE
• 金额: $ 1.33万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606335
• 关键词: Acids; Adopted; Alkalies; Animal Model; Animals; Atkins Diet; Calcium; Calculi; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Diet; Fatty acid glycerol esters; Funding; Goals; Grant; Institution; Intake; Intestines; Kidney Calculi; Potassium; Proteins; Research; Research Personnel; Resources; Risk; Source; Testing; United States National Institutes of Health; absorption; bone loss; bone metabolism; potassium citrate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to continue efforts toward identifying potential deleterious effects of high animal protein diet on bone metabolism and kidney stone formation, and ascertain the value of potassium alkali as a countermeasure. The overall hypotheses to be tested are: 1) a high animal protein intake confers an acid load, which then causes bone loss and increases stone-forming risk, 2) potassium citrate corrects these deleterious effects by "neutralizing" the acid load, 3) intestinal calcium absorption is enhanced by potassium alkali in the setting of an acid load. The model for animal protein excess adopted in this effort is the Atkins' diet, where in the restriction of carbohydrates and liberal intake of fat leads to an exaggerated intake of animal proteins that confers a marked acid load.

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