Environmental influences on Child Health Outcomes in the Northern Plains PASS-ECHO Cohort

环境对北部平原儿童健康结果的影响 PASS-ECHO 队列

• 批准号: 10744504
• 负责人: Amy J Elliott
• 金额: $ 645万
• 依托单位: AVERA MCKENNAN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744504
• 关键词: Adipose tissue; Adolescence; Adult; Agreement; American Indians; Biological; Biological Markers; Body Composition; Body mass index; Body measure procedure; Cardiovascular system; Cheyenne; Child; Child Development; Child Health; Chronic stress; Collaborations; Communities; Conceptions; Consent; Coronary heart disease; Data; Development; Diabetes Mellitus; Disease; Dual-Energy X-Ray Absorptiometry; Dyslipidemias; Eating Behavior; Economics; Education; Enrollment; Ethnic Population; Event; Exposure to; Fatty acid glycerol esters; Feeding behaviors; Female; Foundations; Geography; Gestational Diabetes; Health; Healthy Eating; Individual; Infant; Inflammatory; Insulin Resistance; Joints; Knowledge; Late Effects; Leadership; Life; Life Style; Measures; Mediating; Mental Depression; Metabolic; Mothers; Navajo; Neighborhoods; Neurosecretory Systems; OGTT; Obesity; Outcome; Outcome Measure; Participant; Patients; Pattern; Personal Satisfaction; Phase; Physiological; Policies; Pregnancy; Protocols documentation; Psyche structure; Research; Research Infrastructure; Risk; Risk Factors; Roentgen Rays; Rural; Rural Community; Science; Sioux Indians; South Dakota; Tribes; United States National Institutes of Health; Visceral; allostatic load; built environment; cardiometabolic risk; cardiometabolism; cohort; data sharing; design; early childhood; executive function; follow-up; food security; male; maternal obesity; microbiome composition; middle childhood; mortality; neurodevelopment; nutrition; obesity in children; offspring; participant enrollment; prenatal; prenatal stress; racial diversity; racial population; recruit; rural area; secondary analysis; sex; social health determinants; subcutaneous; success

PROJECT SUMMARY This proposal serves to leverage the Safe Passage Study ECHO (PASS ECHO) research infrastructure that has recruited a large cohort of ECHO mother/child pairs (n=6.647) for continued follow-up, as well as continued enrollment of new pregnancies and initiating a preconception cohort. The success of the PASS ECHO research team from 2016-2023, both in scientific collaboration and completing of operational tasks, provides an excellent foundation for increased enrollment and retention of ECHO participants, including a large proportion of rural and American Indian participants. PASS ECHO has a specialization in the ECHO Obesity health outcome. The following specific aims relate directly to advancing collaborative ECHO Cohort science and completing operational tasks relevant for successful participation in the next phase of ECHO. (SA1) Examine the effects of prenatal allostatic load, and its biomarkers, on childhood obesity and neurodevelopment. (SA2) Examine the independent and joint effects of prenatal life-style related exposures on child obesity-related outcomes, and how nutrition may impact these relationships. (SA3) Build upon demonstrated successful strategies and strong community/participant relationships to implement the ECHO-wide protocol v3.0 with deliberate efforts to increase participation in American Indian and rural communities.

项目总结