Psychotic Symptoms on Visual Learning in Schizophrenia

精神分裂症视觉学习的精神病症状

• 批准号: 6559862
• 负责人: HENRY HILLIARD HOLCOMB
• 金额: $ 40.45万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6559862
• 关键词: behavior test; behavioral /social science research tag; brain electrical activity; cerebral cortex; clinical research; cognition disorders; functional magnetic resonance imaging; hallucinations; human subject; learning; neuroanatomy; neurophysiology; schizophrenia; space perception; visual perception; visual stimulus

DESCRIPTION (provided by applicant): Most, but not all, persons diagnosed with schizophrenia are able to learn when given systematic, repetitive exposure to a perceptual or motor task. In spite of their normal skill acquisition, persons with thought disorder or reality distortion might not be able to learn by using normal brain physiology. The behavioral and physiological impact of particular symptom profiles on perceptual learning has not been assessed in an experimental design explicitly created to generate similar performance across subjects of differing abilities. This proposal will use event related functional magnetic resonance imaging (fMRI) with normal healthy volunteers and persons with schizophrenia, to determine whether thought disorder (disorganization), or reality distortion (hallucinations plus delusions) specifically influence the physiological response to learning a visual / spatial recognition task. We expect thought disorder to have a significantly greater effect on a schizophrenic's neural activity patterns associated with learning, than reality distortion. Thought disorder is hypothesized to diminish hippocampal and frontal cortex response to training, especially during the encode phase of the trial. We will determine the dynamic roles of particular cortical systems in normal subjects before and after visual recognition training. We will then assess the relative impact of these two symptom profiles, in persons with schizophrenia learning a visual Delayed Match to Sample Task (DMST), on the changes found in these regions. We will obtain event related fMRI studies on 30 clinically stable, medicated persons with schizophrenia (15 with thought disorder and 15 with reality distortion) and 25 age and sex matched comparison subjects (normal volunteers) before (first fMRI) and after (second fMRI) visual skill training using a visual DMST. Clinical characteristics, thought disorder (TD) and reality distortion (RD), of the schizophrenic volunteers will be correlated with the physiological (especially encode components of the trial) and behavioral response to visual learning. A third fMRI study after 8 weeks of intensive visual training, will be done on all schizophrenic volunteers following the second study. SZ with predominantly RD may be able to use this extended training to further normalize their task-activated BOLD signal patterns but SZ with predominantly TD may not benefit. Our understanding of how symptom clusters contribute to abnormal physiological activity patterns associated with learning visual recognition.

描述（由申请人提供）：大多数，但不是全部，被诊断为精神分裂症的人能够在系统地，重复地暴露于感知或运动任务时学习。尽管他们有正常的技能习得，但有思维障碍或现实扭曲的人可能无法通过正常的大脑生理学来学习。特定症状对感知学习的行为和生理影响尚未在明确创建的实验设计中进行评估，该实验设计旨在在不同能力的受试者中产生相似的表现。本研究将使用与事件相关的功能性磁共振成像（fMRI）对正常健康志愿者和精神分裂症患者进行研究，以确定思维障碍（混乱）或现实扭曲（幻觉加妄想）是否会特别影响学习视觉/空间识别任务的生理反应。我们预计思维障碍对精神分裂症患者与学习相关的神经活动模式的影响要比现实扭曲大得多。假设思维障碍会减少海马和额叶皮层对训练的反应，特别是在试验的编码阶段。我们将确定在视觉识别训练前后，正常受试者特定皮质系统的动态作用。然后，我们将评估精神分裂症患者学习视觉延迟匹配样本任务（DMST）时这两种症状特征对这些区域变化的相对影响。我们将获得30名临床稳定的精神分裂症患者（15名患有思维障碍，15名患有现实扭曲）和25名年龄和性别匹配的对照受试者（正常志愿者）在使用视觉DMST进行视觉技能训练之前（第一次fMRI）和之后（第二次fMRI）与事件相关的功能磁共振成像研究。精神分裂症志愿者的临床特征、思维障碍（TD）和现实扭曲（RD）将与视觉学习的生理（特别是实验的编码成分）和行为反应相关。在8周的强化视觉训练后，将对所有精神分裂症志愿者进行第三次功能磁共振成像研究。以RD为主的SZ可能能够使用这种扩展训练来进一步规范化其任务激活的BOLD信号模式，但以TD为主的SZ可能不会受益。我们对症状集群如何导致与学习视觉识别相关的异常生理活动模式的理解。