EFFECT OF PSYCHOTIC SYMPTOMS ON VISUAL LEARNING IN SCHIZOPHRENIA, FMRI

精神症状对精神分裂症视觉学习的影响，FMRI

• 批准号: 7376949
• 负责人: HENRY HILLIARD HOLCOMB
• 金额: $ 4.31万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376949
• 关键词: EFFECT; PSYCHOTIC; SYMPTOMS; VISUAL; LEARNING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with schizophrenia are impaired in their ability to make perceptually ambiguous recognitions and often respond poorly to training programs designed to improve the precision of their judgments. This research program is designed to illuminate the physiological mechanisms associated with learning and memory in this impaired group. In particular it will provide information specifically concerning the relationship between a person's symptoms and his capacity to change brain activity patterns and brain chemistry associated with learning and practice. The principal objectives of the study include finding out: a) what brain structures are associated with encoding initial presentations of visual stimuli that are to be remembered versus those that are not targets of memory; b) how does visual learning and training alter the neural pathways associated with encoding; c) to what extent do all volunteers with schizophrenia differ from normal healthy volunteers in their functional neural architecture associated with encoding before and after training; d) to what extent does a schizophrenic patient's symptoms (especially psychosis) determine the activation of neural systems associated with encoding, before and after training; e) will extended visual training 'normalize' the neural activity patterns in those with schizophrenia; f) the relation of neurochemistry to neural activity associated with learning before and after training. We will assess performance improvement on a visual Delayed Match to Sample Task (DMST) in normal volunteers (NV) and schizophrenia volunteers (SZ). We propose to recruit 30 SZ. A total of 25 NV will be matched with SZ on age, sex, and familial socioeconomic class (SES). There will be an initial screening of all. The neuropsychological task for the imaging experiment is the visual Delayed Match to Sample Task (DMST). NV and SZ will receive a pre-training fMRI and their performance on the visual DMST will be quantified. A training period of 4 sessions over two weeks on the DMST will be provided for all volunteers. After training, NV and SZ will receive a post-training fMRI and an MRS study. SZ, after the initial fMRI, four training sessions and second, post-training fMRI, will participate in a longer and more intensive practice over the subsequent one month. Two sessions weekly over 4 weeks will produce an over-trained condition. We will contrast the scans, fMRI and MRS (Scan 2 versus Scan 3) collected at the end of the one-month extension period between the two symptom groups.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。精神分裂症患者做出模糊认知的能力受损，对旨在提高他们判断准确性的训练项目往往反应不佳。本研究计划旨在阐明与这一受损群体的学习和记忆相关的生理机制。特别是，它将提供有关一个人的症状与其改变大脑活动模式的能力以及与学习和实践有关的大脑化学物质之间关系的具体信息。这项研究的主要目的包括发现：a)哪些大脑结构与要被记住的视觉刺激的初始呈现的编码有关，哪些不是记忆的目标；B)视觉学习和训练如何改变与编码相关的神经通路；C)所有精神分裂症志愿者在训练前后与编码相关的功能神经结构与正常健康志愿者的差异程度；D)在训练前后，精神分裂症患者的症状（尤其是精神病）在多大程度上决定了与编码相关的神经系统的激活；E)延长视觉训练是否会使精神分裂症患者的神经活动模式“正常化”？F)训练前后与学习相关的神经化学与神经活动的关系。我们将评估正常志愿者（NV）和精神分裂症志愿者（SZ）在视觉延迟匹配样本任务（DMST）上的表现改善。我们拟招聘30名SZ。根据年龄、性别和家庭社会经济阶层（SES），将25名NV与SZ进行匹配。将对所有人进行初步筛选。成像实验的神经心理学任务是视觉延迟匹配任务（DMST）。NV和SZ将接受预训练fMRI，他们在视觉DMST上的表现将被量化。为所有义工提供为期两周的四次DMST培训。训练结束后，NV和SZ将接受训练后的功能磁共振成像和磁共振成像研究。SZ在第一次fMRI、四次训练和第二次训练后的fMRI之后，将在接下来的一个月里进行更长、更密集的练习。每周两次训练超过4周会导致过度训练。我们将对比两个症状组在一个月延长期结束时收集的扫描结果，fMRI和MRS（扫描2和扫描3）。