Psychotic Symptoms on Visual Learning in Schizophrenia

精神分裂症视觉学习的精神病症状

• 批准号: 6837610
• 负责人: HENRY HILLIARD HOLCOMB
• 金额: $ 37.58万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6837610
• 关键词: Psychotic; Symptoms; Visual; Learning; Schizophrenia

Principal Investigator/Program Director (Last, first, middle): Holcomb, Henry H. DESCRIPTION. State the application's broad, tong-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research desLgn and methods for achieving these goals. Avoid summaries of past accomplishments and the use of the first person. This abstract iS meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE 8PACE PROVIDED. Most, but not all, persons diagnosed with schizophrenia are able to learn when given systematic, repetitive exposure to a perceptual or motor task. In spite of their normal skill acquisition, persons with thought disorder or reality distortion might not be able to learn by using normal brain physiology. The behavioral and physiological impact of particular symptom profiles on perceptual learning has not been assessed in an experimental design explicitly created to generate similar performance across subjects of differing abilities. This proposal will use event related functional magnetic resonance imaging (fMRI) with normal healthy volunteers and persons with schizophrenia, to determine whether thought disorder (disorganization), or reality distortion (hallucinations plus delusions) specifically influence the physiological response to learning a visual / spatial recognition task. We expect thought disorder to have a significantly greater effect on a schizophrenic's neural activity patterns associated with learning, than reality distortion. Thought disorder is hypothesized to diminish hippocampal and frontal cortex response to training, especially during the encode phase of the trial. We will determine the dynamic roles of particular cortical systems in normal subjects before and after visual recognition training. We will then assess the relative impact of these two symptom profiles, in persons with schizophrenia learning a visual Delayed Match to Sample Task (DMST), on the changes found in these regions. We will obtain event related fMRI studies on 30 clinically stable, medicated persons with schizophrenia (15 with thought disorder and 15 with reality distortion) and 25 age and sex matched comparison subjects (normal volunteers) before (first fMRI) and after (second fMRI) visual skill training using a visual DMST. Clinical characteristics, thought disorder (TD) and reality distortion (RD), of the schizophrenic volunteers will be correlated with the physiological (especially encode components of the trial) and behavioral response to visual learning. A third fMRI study after 8 weeks of intensive visual training, will be done on all schizophrenic volunteers following the second study. SZ with predominantly RD may be able to use this extended training to further normalize their task-activated BOLD signal patterns but SZ with predominantly TD may not benefit. Our understanding of how symptom clusters contribute to abnormal physiological activity patterns associated with learning visual recognition. PERFORMANCE SITE ========================================Section End===========================================

主要研究者/项目负责人（最后，第一，中间）：Holcomb，亨利H。说明.说明申请的广泛、长期目标和具体目标，并参考项目的健康相关性。简要描述研究设计和实现这些目标的方法。避免总结过去的成就和使用第一人称。本摘要旨在作为与应用程序分离时所提出的工作的简洁和准确的描述。如果申请获得资助，此描述将成为公共信息。因此，不包括专有/机密信息。不要超过所提供的8步。大多数，但不是全部，被诊断患有精神分裂症的人能够在系统地、重复地暴露于知觉或运动任务时学习。尽管有正常的技能习得，但有思维障碍或现实扭曲的人可能无法通过使用正常的大脑生理学来学习。特定症状特征对感知学习的行为和生理影响尚未在明确创建的实验设计中进行评估，以在不同能力的受试者中产生相似的表现。该提案将使用事件相关的功能磁共振成像（fMRI）与正常健康志愿者和精神分裂症患者，以确定是否思维障碍（混乱），或现实扭曲（幻觉加妄想）具体影响学习视觉/空间识别任务的生理反应。我们认为思维障碍对精神分裂症患者与学习相关的神经活动模式的影响要比现实扭曲大得多。假设思维障碍会减少海马和额叶皮层对训练的反应，特别是在试验的编码阶段。我们将确定特定的皮质系统在正常受试者的视觉识别训练前后的动态作用。然后，我们将评估这两个症状的相对影响，在学习视觉延迟匹配到样本任务（DMST）的精神分裂症患者，在这些地区发现的变化。我们将获得事件相关的功能磁共振成像研究30临床稳定，药物治疗的精神分裂症患者（15与思维障碍和15与现实扭曲）和25个年龄和性别匹配的比较对象（正常志愿者）之前（第一次功能磁共振成像）和之后（第二次功能磁共振成像）的视觉技能训练使用视觉DMST。精神分裂症志愿者的临床特征，思维障碍（TD）和现实扭曲（RD），将与视觉学习的生理（特别是试验的编码成分）和行为反应相关。在第二项研究之后，将对所有精神分裂症志愿者进行为期8周的强化视觉训练后的第三项fMRI研究。具有主要RD的SZ可以能够使用该扩展训练来进一步使其任务激活的BOLD信号模式正常化，但是具有主要TD的SZ可能不会受益。我们对症状群如何导致与学习视觉识别相关的异常生理活动模式的理解。性能现场=