EFFECT OF PSYCHOTIC SYMPTOMS ON VISUAL LEARNING IN SCHIZOPHRENIA, FMRI

精神症状对精神分裂症视觉学习的影响，FMRI

• 批准号: 7608136
• 负责人: HENRY HILLIARD HOLCOMB
• 金额: $ 0.46万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608136
• 关键词: Age; Architecture; Brain; Brain Chemistry; Class; Computer Retrieval of Information on Scientific Projects Database; Condition; Functional Magnetic Resonance Imaging; Funding; Grant; Image; Institution; Judgment; Learning; Magnetic Resonance Spectroscopy; Memory; Neural Pathways; Patients; Pattern; Performance; Persons; Physiological; Psychotic Disorders; Recruitment Activity; Research; Research Personnel; Resources; Sampling; Scanning; Schizophrenia; Screening procedure; Source; Structure; Symptoms; System; Training; Training Programs; United States National Institutes of Health; Visual; Week; design; healthy volunteer; improved; neurochemistry; neuropsychological; programs; relating to nervous system; research study; sex; socioeconomics; visual learning; visual stimulus; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with schizophrenia are impaired in their ability to make perceptually ambiguous recognitions and often respond poorly to training programs designed to improve the precision of their judgments. This research program is designed to illuminate the physiological mechanisms associated with learning and memory in this impaired group. In particular it will provide information specifically concerning the relationship between a person's symptoms and his capacity to change brain activity patterns and brain chemistry associated with learning and practice. The principal objectives of the study include finding out: a) what brain structures are associated with encoding initial presentations of visual stimuli that are to be remembered versus those that are not targets of memory; b) how does visual learning and training alter the neural pathways associated with encoding; c) to what extent do all volunteers with schizophrenia differ from normal healthy volunteers in their functional neural architecture associated with encoding before and after training; d) to what extent does a schizophrenic patient's symptoms (especially psychosis) determine the activation of neural systems associated with encoding, before and after training; e) will extended visual training 'normalize' the neural activity patterns in those with schizophrenia; f) the relation of neurochemistry to neural activity associated with learning before and after training. We will assess performance improvement on a visual Delayed Match to Sample Task (DMST) in normal volunteers (NV) and schizophrenia volunteers (SZ). We propose to recruit 30 SZ. A total of 25 NV will be matched with SZ on age, sex, and familial socioeconomic class (SES). There will be an initial screening of all. The neuropsychological task for the imaging experiment is the visual Delayed Match to Sample Task (DMST). NV and SZ will receive a pre-training fMRI and their performance on the visual DMST will be quantified. A training period of 4 sessions over two weeks on the DMST will be provided for all volunteers. After training, NV and SZ will receive a post-training fMRI and an MRS study. SZ, after the initial fMRI, four training sessions and second, post-training fMRI, will participate in a longer and more intensive practice over the subsequent one month. Two sessions weekly over 4 weeks will produce an over-trained condition. We will contrast the scans, fMRI and MRS (Scan 2 versus Scan 3) collected at the end of the one-month extension period between the two symptom groups.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 精神分裂症患者做出模糊判断的能力受损，并且通常对旨在提高其判断精度的训练计划反应不佳。这项研究计划的目的是阐明与学习和记忆在这个受损的群体相关的生理机制。特别是，它将提供有关一个人的症状和他改变大脑活动模式和与学习和实践相关的大脑化学的能力之间的关系的具体信息。本研究的主要目的包括：a）与那些不是记忆目标的视觉刺激相比，哪些大脑结构与编码视觉刺激的初始呈现相关; B）视觉学习和训练如何改变与编码相关的神经通路; c）、精神分裂症志愿者与正常健康志愿者在编码之前和之后的功能神经结构有什么不同？培训; d）在训练前后，精神分裂症患者的症状（尤其是精神病）在多大程度上决定了与编码相关的神经系统的激活; e）延长的视觉训练是否会使精神分裂症患者的神经活动模式“正常化”; f）神经化学与训练前后与学习相关的神经活动的关系。我们将评估正常志愿者（NV）和精神分裂症志愿者（SZ）在视觉延迟匹配样本任务（DMST）上的表现改善。我们计划招募30名SZ。共有25名NV将在年龄、性别和家庭社会经济阶层（SES）方面与SZ匹配。将对所有人进行初步筛选。成像实验的神经心理学任务是视觉延迟匹配样本任务（DMST）。NV和SZ将接受训练前的功能磁共振成像，并量化他们在视觉DMST上的表现。将为所有志愿者提供为期两周的4次DMST培训。培训结束后，NV和SZ将接受培训后fMRI和MRS研究。SZ，在最初的功能磁共振成像，四个培训课程和第二，培训后的功能磁共振成像，将参加在随后的一个月更长，更密集的实践。每周两次超过4周将产生过度训练的条件。我们将对比两个症状组在一个月延长期结束时收集的扫描，fMRI和MRS（扫描2与扫描3）。