AUTOMATED 3D TISSUE CHANGE DETECTION/QUANTIFICATION

自动 3D 组织变化检测/量化

• 批准号: 6656984
• 负责人: TIMOTHY J HOLMES
• 金额: $ 45.02万
• 依托单位: LICKENBROCK TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656984
• 关键词: bioimaging /biomedical imaging; biomedical automation; cell component structure /function; computer data analysis; computer program /software; computer system design /evaluation; digital imaging; histology; image processing; immunochemistry; laboratory rat; method development; morphology; morphometry; neurochemistry; three dimensional imaging /topography; tissue /cell culture

DESCRIPTION (Applicant's abstract verbatim): The broad, long-term commercial objective of this project is to produce a prototype software system that leads to a profitable product for tissue characterization by 3D image processing, with a broad popularity among neuroscientists, biologists, industrial pharmacology, food science and other broad applications. The long-term scientific objective is to provide a means for accurately, quickly and economically detecting and monitoring the 3D character of tissue, with a focus on applications in detecting changes in neurological (brain) experimental animal tissue due to specific agents. The innovations of this work are: (1) the novel extension of automated feature extraction and tissue characterization methods to that of 3D image processing, (2) novel extensions and new approaches to such algorithms that will make the algorithm robust against adverse laboratory conditions, (3) developing the first commercial product that comprehensively analyzes the 3D character of biological tissue, (4), a Strategic approach to balancing the amount of labor required by the experimenter to maintain full control over the experiment and to maintain confidence in the results of the experiment versus the level of automation necessary to eliminate tedium, inaccuracies and the prohibitive amount of work that is otherwise necessary in carrying out such comprehensive characterizations, and (5), a novel interactive 3D editor system, which will provide quick, powerful and easy-to-operate 3D point-and-click image editing and 3D morphometric measurement. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（申请人的摘要逐字）：广泛的，长期的商业 这个项目的目标是产生一个原型软件系统，导致 涉及通过3D图像处理进行组织表征的有利产品， 在神经科学家、生物学家、工业界 药理学、食品科学和其他广泛的应用。长期 科学的目标是提供一种方法，准确，快速， 经济地检测和监测组织的3D特征， 在检测神经（脑）实验变化中的应用 动物组织中的特定物质。本文的创新之处在于：（1） 自动特征提取和组织表征的新扩展 方法的三维图像处理，（2）新的扩展和新的方法 这些算法将使算法对不利的 实验室条件下，（3）开发第一个商业产品， 全面分析了生物组织的三维特征， 战略方针，以平衡劳动力所需的数量， 实验者保持对实验的完全控制，并保持 对实验结果的信心与自动化水平 必要的，以消除繁琐，不准确和禁止的工作量 这是在进行这种全面的必要的， 特征，和（5），一个新的交互式三维编辑系统，这将 提供快速、强大且易于操作的3D点击式图像编辑 和3D形态测量。 拟定商业应用： 不可用