Photoreceptor Integrity Software

感光器完整性软件

• 批准号: 8311455
• 负责人: TIMOTHY J HOLMES
• 金额: $ 14.83万
• 依托单位: LICKENBROCK TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311455
• 关键词: Address; Affect; Age related macular degeneration; Algorithms; American; Appearance; Automation; Blindness; Choroid; Clinic; Clinical; Computer software; Data; Data Set; Detection; Development; Disease; Elements; Eye; Face; Functional disorder; Future; Image; Imagery; Link; Manuals; Measurement; Measures; Membrane; Optical Coherence Tomography; Optics; Pathologic; Patients; Phase; Photoreceptors; Physiology; Process; Research; Research Personnel; Retina; Retinal; Retinitis Pigmentosa; Role; Specialist; Structure of retinal pigment epithelium; Surface; Technology; Telangiectasis; Testing; Time; Vision; Work; design; geographic atrophy; human subject; innovation; macula; novel; operation; prototype; research clinical testing; study characteristics; tool

DESCRIPTION (provided by applicant): This research will have a significant and potentially broad impact on reducing blindness and vision loss of Americans. Many predominant eye conditions, associated with blindness and vision loss, disturb and compromise the photoreceptors. This research will enable researchers to study the characteristics, causes and future treatments of diseases and conditions that affect photoreceptors. The ensuing software product will produce images of the photoreceptor- integrity layer (PIL), and related nearby layers, which are endogenous markers of the photoreceptors and are linked to many predominant blinding diseases. The software will be sold initially to researchers of the causes and treatments of these diseases and, later, it will be aimed at clinical use, for evaluating conditions to manage treatments. The Phase I project involves the study and development of algorithms and software that produce images and measurements from optical coherence tomography in and near the photoreceptor layer - starting most notably with the PIL that is traditionally thought to represent the inner-segment/outer-segment junction and is a component of the photoreceptors. These layers are connected physically and physiologically to the photoreceptors, so their compromise affects vision loss in many predominant conditions such as age-related macular degeneration, geographic atrophy and retinitis pigmentosa. The software will help researchers characterize and study the progression and pathophysiology of these conditions. It will provide objective measures for practitioners to evaluate these conditions to manage treatment. The most important novelties are: (1) It will have full automation, with no manual operations needed, which is essential for practitioners. (2) A unique set of images and measures are defined for research and practical clinical use. (3) A novel mathematical approach that involves, for the first time, 3D active surface contours and a novel optimization function designed by our group. (4) It will be the first commercial product with this functionality. Easy-to use images and measures are aimed at the dual role of a research tool and a clinical evaluation tool where workflow is important. This commercial aim causes many challenges that will drive further innovations of the algorithms and software. The Phase I project will focus on the first prototype algorithms and approaches to producing images and measurements, in order to demonstrate the feasibility of the technology. Measurements include those of parameters that could reflect any compromise of the PIL. Feasibility will be defined by showing that these measures show a difference between normal and disease cases. Phase II will involve algorithms and images for studying other layers besides the PIL layer that are connected physiologically and physically to the photoreceptors, including the retinal pigment epithelium and external limiting membrane. The detection and visualization of other layers in the retina and choroid will be a natural fallout of this work, so the end product will have a wealth of functionalty demanded by the customers, besides imaging and measurement of layers relevant to the photoreceptors, although the focus and aim of the Phase I and Phase II work will be associated with the photoreceptors. PUBLIC HEALTH RELEVANCE: This research will have a significant and potentially broad impact on reducing blindness and vision loss of Americans. Many predominant eye conditions that cause blindness and vision loss are accompanied by compromised photoreceptors. This research will enable researchers to study the characteristics, causes and future treatments of diseases and conditions that affect photoreceptors. The ensuing software product will produce images of the photoreceptor- integrity layer (PIL), and related nearby layers, which are endogenous markers of the photoreceptors and are linked to many predominant blinding diseases. The software will be sold initially to researchers of the causes and treatments of these diseases and, later, it will be aimed at clinical use, for evaluating conditions to manage treatments. The theme of this project is the study and development of algorithms and software that produce measurements and images from optical coherence tomography (OCT) retinal layers associated with the photoreceptors - most notably and initially the photoreceptor-integrity layer (PIL). The software is intended for studying, characterizing and managing treatment of conditions that disturb the photoreceptors. The disturbance of the PIL and these other layers (e.g., retinal pigment epithelium and external limiting membrane), because they are connected physically and physiologically to the photoreceptors (photosensitive elements of the eye), affect vision in common blinding diseases and conditions such as age- related macular degeneration (AMD), geographic atrophy (a condition of AMD), retinitis pigmentosa, macular telangiectasia and others. The software's earliest version will have tools for researchers to characterize and study the progression and physiology of these conditions. A later version will provide objective images and measures for practitioners to evaluate these conditions and manage treatment. The software product will produce easy-to-understand measures specifically aimed at the dual role of a research tool and a clinical evaluation tool where workflow of the clinic is important. A prototype will be produced that leads to a commercial software package that is easy to use by many researchers and practitioners.

描述（由申请人提供）：这项研究将对减少美国人的失明和视力丧失产生重大且潜在的广泛影响。许多与失明和视力丧失相关的主要眼睛条件，会干扰和损害光感受器。这项研究将使研究人员能够研究影响光感受器的疾病和疾病的特征，原因和未来治疗方法。随后的软件产品将产生光感受器完整性层（PIL）以及附近相关层的图像，它们是感光体的内源性标记物，并与许多主要的盲目疾病有关。该软件最初将出售给研究人员的这些疾病原因和治疗方法，后来它将针对临床使用，以评估管理治疗的疾病。第一阶段项目涉及算法和软件的研究和开发，这些算法和软件从光感受器层内和附近产生图像和测量 - 最著名的是从传统上认为代表内部段/外部段连接的PIL开始，并且是光感受器的一个组件。这些层在物理和生理上与感光体相连，因此它们的折衷会影响许多主要条件的视力丧失，例如与年龄相关的黄斑变性，地理萎缩和色素性视网膜炎。该软件将帮助研究人员表征和研究这些疾病的进展和病理生理学。它将为从业者提供客观措施，以评估这些条件以管理治疗。最重要的新颖性是：（1）它将具有完整的自动化，而无需手动操作，这对于从业者来说至关重要。 （2）为研究和实际临床使用定义了一组独特的图像和措施。 （3）一种新型的数学方法，该方法首次涉及3D活动表面轮廓和我们组设计的新型优化函数。 （4）这将是第一个具有此功能的商业产品。易于 使用图像和措施针对研究工具的双重作用和工作流程很重要的临床评估工具。这个商业目标会引起许多挑战，这些挑战将推动算法和软件的进一步创新。第一阶段项目将重点介绍第一个原型算法和生产图像和测量的方法，以证明技术的可行性。测量包括可能反映PIL的任何妥协的参数。可行性将通过表明这些措施显示正常情况和疾病病例之间的差异来定义。第二阶段将涉及算法和图像，用于研究除PIL层以外的其他层，这些层在生理和物理上连接到感光体，包括视网膜色素上皮和外部限制膜。视网膜和脉络膜中其他层的检测和可视化将是这项工作的自然后果，因此，除了与光感受器相关的层的成像和测量外，最终产品将具有大量的功能，尽管I阶段和II期工作的焦点和目标将与光感受器相关。 公共卫生相关性：这项研究将对减少美国人的失明和视力丧失产生重大且潜在的广泛影响。许多导致失明和视力丧失的主要眼病伴随着受损的光感受器。这项研究将使研究人员能够研究影响光感受器的疾病和疾病的特征，原因和未来治疗方法。随后的软件产品将产生光感受器完整性层（PIL）以及附近相关层的图像，它们是感光体的内源性标记物，并与许多主要的盲目疾病有关。该软件最初将出售给研究人员的这些疾病原因和治疗方法，后来它将针对临床使用，以评估管理治疗的疾病。该项目的主题是研究和开发算法和软件，这些算法和软件从光学相干断层扫描（OCT）视网膜层中产生与光感受器相关的视网膜层的测量和图像 - 最值得注意的是，最初是光感受器积分层（PIL）。该软件旨在研究，表征和管理干扰光感受器的疾病的处理。 PIL和这些其他层的干扰（例如，视网膜色素上皮和外部有限膜），因为它们在物理和生理上与感光体（眼睛的光敏元素）在物理和生理上连接，会影响常见的盲目疾病的视力和年龄相关的黄斑变性（AMD），地理位置（Amdiation），antife and Amdia，andia，antife and and tifor nive and and and tiste and and tiste and and tistion and andia。还有其他。该软件最早的版本将为研究人员提供特征和研究这些疾病的进展和生理的工具。以后的版本将为从业人员提供客观的图像和措施，以评估这些情况并管理治疗。该软件产品将产生易于理解的措施，专门针对研究工具的双重作用和临床评估工具，其中诊所的工作流程很重要。将生产一个原型，该原型会导致许多研究人员和从业人员易于使用的商业软件包。