Estrogenic Component of the Vascular Etiology of Alzheimer's Disease

阿尔茨海默病血管病因学中的雌激素成分

• 批准号: 10713773
• 负责人: S MICHAL JAZWINSKI
• 金额: $ 38.23万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713773
• 关键词: Address; Adopted; Aging; Alzheimer' s Disease; Area; Bioinformatics; Biological Aging; Biological Process; Biomedical Research; Cell Proliferation; Cementation; Centers of Research Excellence; Chronic Disease; Clinical; Collaborations; Communities; Core Facility; Dedications; Degenerative Disorder; Development; Disease; Educational workshop; Elements; Environment; Etiology; Extramural Activities; Faculty; Feedback; Foundations; Funding; Genome Stability; Genomics; Goals; Grant; Growth; Health; Homeostasis; Immunity; Inflammaging; Inflammation; Infrastructure; Institution; Interdisciplinary Study; Intervention; Knowledge; Life; Life Expectancy; Longevity; Maintenance; Measures; Mentors; Metabolic; Musculoskeletal; Natural regeneration; Neurocognitive; Pathogenesis; Phase; Physical Function; Pilot Projects; Positioning Attribute; Preventive; Process; Program Description; Program Development; Public Health; Quality of life; Regenerative Medicine; Regenerative research; Regulation; Research; Research Infrastructure; Research Personnel; Retirement; Risk Factors; Services; Talents; Therapeutic Intervention; Time; Training; Training Programs; Twin Multiple Birth; Universities; Update; aging population; aspirate; baby boomer; base; career development; cognitive function; cohort; design; estrogenic; expectation; improved; interest; medical schools; molecular imaging; multidisciplinary; neuroinflammation; programs; psychosocial; soft tissue; stem cell function; success; sustainable resource; therapeutic development; vascular factor; wound healing

Aging is a biological process that is the major risk factor for chronic disease and degeneration during the lifespan. However, it is beginning to be appreciated that disease and degeneration impinge on the aging process, in something akin to a feedback loop, suggesting that a better knowledge of one contributes to an understanding of the other. This necessitates that development of therapeutic interventions must address the degenerative disorders of aging, while the search for broad interventions that target the biological aging process itself continues. The agenda just described calls for the creation and nurturing of an environment in which multidisciplinary research of sufficient breadth is focused on key elements of aging and regeneration. At the same time, it is necessary to populate this translational space with talented and successful investigators. Our Phase I and II COBRE launched and further propelled us in this direction by allowing us to seed several key research topics with ambitious junior investigators, who in just nine years have advanced to independently funded status with remarkable success. Our task is not yet done, however, if we are to maintain momentum and a critical mass of investigators dedicated to aging and regenerative medicine. COBRE Phase III will allow us to continue to grow our cadre of dedicated investigators through our pilot projects and by enriching the research environment through our mentoring and training programs, as well as topical seminars. These efforts will be aided by the maintenance of a state-of-the-art Genomics, Bioinformatics, and Molecular Imaging Core that has a sustaining revenue base. Our emphasis is on multiplying the opportunities for interactions that will generate collaborative projects that are synergistic and competitive for multicomponent project grant funding. Our goals are to: (1) Continue to expand the number of aging and regeneration research-oriented, funded investigators within our scientific community through our pilot projects, with emphasis on collaborative research, and to provide a mentoring program for these researchers and others that supports successful career development. (2) Maintain our state-of-the-art infrastructure to provide sustainable resources that continuously enhance the competitiveness of our faculty for national funding, by expanding and updating the services performed by our Genomics, Bioinformatics, and Molecular Imaging Core. (3) Cement the position of the Tulane Center for Aging at the forefront of aging and regenerative medicine by growth of our thematic, multidisciplinary research foci to facilitate successful extramurally funded collaborations that will support and sustain the center. This effort will be supported by our research workshops, training and career development programs, and seminars.

衰老是一个生物过程，是慢性疾病和退化的主要危险因素 寿命。然而，人们开始认识到疾病和退化会影响衰老 过程，类似于反馈循环，表明更好地了解一个人有助于 对对方的理解。这使得治疗干预措施的发展必须解决以下问题： 衰老的退行性疾病，同时寻找针对生物衰老的广泛干预措施 过程本身仍在继续。刚才的议程描述了呼吁创造和培育一个环境 该研究具有足够广度的多学科研究重点关注衰老和再生的关键要素。在 同时，有必要为这个转化空间注入才华横溢、成功的研究人员。 我们的第一期和第二期 COBRE 启动并进一步推动我们朝这个方向发展，让我们能够播种几个 雄心勃勃的初级研究人员在关键研究课题上的表现，他们在短短九年内就已经晋升为独立研究人员 资助地位取得了显着的成功。然而，如果我们要保持势头，我们的任务还没有完成 以及大量致力于衰老和再生医学的研究人员。 COBRE 第三阶段将允许 我们将通过试点项目和丰富研究内容，继续培养专门调查人员的队伍 通过我们的指导和培训计划以及专题研讨会提供研究环境。这些努力 将得到最先进的基因组学、生物信息学和分子成像核心的维护的帮助 拥有持续的收入基础。我们的重点是增加互动的机会 生成具有协同作用且具有竞争力的多组成部分项目拨款资助的合作项目。 我们的目标是：（1）继续扩大以衰老和再生研究为导向、资助的数量 我们科学界的研究人员通过我们的试点项目，重点是协作 研究，并为这些研究人员和其他支持成功的人提供指导计划 职业发展。 (2) 维护我们最先进的基础设施，以提供可持续的资源 通过扩大和更新教师队伍，不断增强教师争取国家资助的竞争力 由我们的基因组学、生物信息学和分子成像核心提供的服务。 （三）巩固地位 通过我们的主题的发展，杜兰大学老龄化中心处于老龄化和再生医学的最前沿， 多学科研究焦点，以促进成功的校外资助合作，这将支持和 支撑中心。这项努力将得到我们的研究研讨会、培训和职业发展的支持 计划和研讨会。