Core--Clinical

描述：(改编自应用程序) ADRC的临床核心--核心B的主要职能是： 招募、描述和跟踪受试者，作为其临床和 对正常衰老和阿尔茨海默病的神经生物学研究；并提供 JHMI所有参与老龄化调查的调查人员的资源 和AD，包括临床试验、基因研究、成像研究和 脑的神经病理神经化学分析。因为认知 老年人的表现差异很大，从正常认知到 严重痴呆症，核心B的工作人员已经召集了几个队列(~700 受试者)来检查与老年人相关的认知状态的全谱 年龄。然而，核心B的核心是对非痴呆的研究 老年受试者和AD早期患者。因此，核心B具有 招募了500名BLSA正常受试者以及约100名患有早期疾病的受试者 AD和75个对照组(队列2)，以及其余25个严重 原始ADRC队列中的精神错乱成员(队列1)。值得注意的是， 在上一个资助期招募的所有AD患者中，超过三分之一的人 非洲裔美国人，这是一个在AD研究中代表性不足的群体。 队列1和2用于AD的研究，而BLSA队列用于AD的研究 是我们临床和神经病理学研究的重点。 衰老和早期痴呆症。生物统计和数据中心，有工作人员 由具有统计方法专业知识的专业人员进行纵向 数据管理的研究和分析方法、收集的功能、 维护和分析所有受试者的人口统计和临床信息 以及促进数据共享的努力，特别是与ADC数据的共享 协调中心。核心B的工作人员拥有神经学方面的专业知识， 精神病学、生物统计学和护理学，与调查人员密切互动 在核心C中，支持项目4的研究。补充调查 在我们ADRC的实验模型(项目1-3)中，核心B是核心 ADRC中所有人类受试者研究的临床资源和 JHMI的其他调查人员。

DESCRIPTION: (Adapted from the application) The principal functions of Core B, the Clinical Core of the ADRC, are: to recruit, characterize, and follow subjects as part of their clinical and neurobiological investigations of normal aging and AD; and to provide a resource for all investigators at JHMI involved in the investigation of aging and AD, including clinical trials, genetic studies, imaging studies, and neuropathological neurochemical analyses of brain. Because cognitive performance in the elderly varies widely, ranging from normal cognition to severe dementia, the staff of Core B has assembled several cohorts (~700 subjects) to examine the full spectrum of cognitive states associated with old age. The centerpiece of Core B, however, is investigations of nondemented elderly subjects and patients in the early stages of AD. Thus, Core B has enrolled 500 normal subjects of the BLSA, as well as ~100 subjects with early AD and 75 controls (Cohort 2), in addition to the remaining 25 severely demented members of the original ADRC cohort (Cohort 1). Significantly, more than one-third of all AD patients recruited in the last funding period were African-Americans, a group which has been under-represented in studies of AD. Cohorts 1 and 2 are used for our investigations of AD, whereas the BLSA cohort serves as the focus for our clinical, and neuropathological studies of normal aging and early stages of dementia. The Biostatistics & Data Center, staffed by professionals with expertise in statistical methods for longitudinal studies and analytical approaches to data management, functions to collect, maintain, and analyze the demographic and clinical information on all subjects and to facilitate data sharing efforts, particularly with the ADC Data Coordinating Center. The staff of Core B, with expertise in neurology, psychiatry, biostatistics, and nursing, interacts closely with investigators in Core C and supports research in Project 4. Complementing the investigations of experimental models (Projects 1-3) in our ADRC, Core B is a central clinical resource for all investigations of human subjects in the ADRC and for other investigators at JHMI.