Core--Clinical

描述：（改编自应用程序） 核心B（ADRC的临床核心）的主要职能是： 招募、表征和随访受试者，作为其临床和 正常衰老和AD的神经生物学研究;并提供 JHMI所有参与老化调查的调查人员的资源 和AD，包括临床试验、遗传研究、成像研究，以及 大脑的神经病理学神经化学分析。因为认知 老年人的表现差异很大，从正常的认知到 严重痴呆症，核心B的工作人员已经收集了几个队列（约700 受试者）检查与老年人相关的认知状态的全谱 年龄然而，核心B的核心是对非痴呆患者的研究。 老年受试者和AD早期患者。因此，核心B具有 入组了500名BLSA正常受试者，以及约100名早期 AD和75例对照（队列2），以及其余25例严重 原始ADRC队列（队列1）的痴呆成员。重要的是，更多 在上一个资助期招募的所有AD患者中， 非裔美国人，一个在AD研究中代表性不足的群体。 队列1和队列2用于我们的AD研究，而BLSA队列 作为我们临床和神经病理学研究的重点， 老年痴呆症的早期阶段。生物统计学和数据中心，工作人员 由具有统计方法专长的专业人员进行 数据管理的研究和分析方法，收集的功能， 维护并分析所有受试者的人口统计学和临床信息 并促进数据共享工作，特别是与ADC数据 协调中心。核心B的工作人员具有神经病学方面的专业知识， 精神病学，生物统计学和护理，与研究人员密切互动 在核心C和支持项目4的研究。补充调查 实验模型（项目1-3）在我们的ADRC，核心B是一个中心 ADRC中所有人类受试者研究的临床资源， JHMI的其他调查人员。

DESCRIPTION: (Adapted from the application) The principal functions of Core B, the Clinical Core of the ADRC, are: to recruit, characterize, and follow subjects as part of their clinical and neurobiological investigations of normal aging and AD; and to provide a resource for all investigators at JHMI involved in the investigation of aging and AD, including clinical trials, genetic studies, imaging studies, and neuropathological neurochemical analyses of brain. Because cognitive performance in the elderly varies widely, ranging from normal cognition to severe dementia, the staff of Core B has assembled several cohorts (~700 subjects) to examine the full spectrum of cognitive states associated with old age. The centerpiece of Core B, however, is investigations of nondemented elderly subjects and patients in the early stages of AD. Thus, Core B has enrolled 500 normal subjects of the BLSA, as well as ~100 subjects with early AD and 75 controls (Cohort 2), in addition to the remaining 25 severely demented members of the original ADRC cohort (Cohort 1). Significantly, more than one-third of all AD patients recruited in the last funding period were African-Americans, a group which has been under-represented in studies of AD. Cohorts 1 and 2 are used for our investigations of AD, whereas the BLSA cohort serves as the focus for our clinical, and neuropathological studies of normal aging and early stages of dementia. The Biostatistics & Data Center, staffed by professionals with expertise in statistical methods for longitudinal studies and analytical approaches to data management, functions to collect, maintain, and analyze the demographic and clinical information on all subjects and to facilitate data sharing efforts, particularly with the ADC Data Coordinating Center. The staff of Core B, with expertise in neurology, psychiatry, biostatistics, and nursing, interacts closely with investigators in Core C and supports research in Project 4. Complementing the investigations of experimental models (Projects 1-3) in our ADRC, Core B is a central clinical resource for all investigations of human subjects in the ADRC and for other investigators at JHMI.