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Harvesting the Photonic Properties of Self-Organising Bacteria Colonies

收获自组织细菌菌落的光子特性

基本信息

批准号：
2110570
负责人：
金额：
--
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2110570
关键词：
Harvesting Photonic Properties Self Organising

项目摘要

The overarching aim of the project is to investigate and utilise the photonic properties of colonies of a novel type of Flavobacterium (strain IR1), which self-assembles into photonic crystals. The strain is a rod-shaped marine bacterium with a diameter of roughly 400nm, that packs in colonies with a tight hexagonal lattice. The colonies appear bright, sparkling green since a part of the visible spectrum is strongly reflected by this organisation. The effect can be described by photonic crystal theory and does not involve pigmentation. In particular we wish to understand:(i) how light scattering relates to the structural organisation (periodicity, regularity) such that we can screen them optically;(ii) how genetic modifications change the optical properties and reveal the important genetic pathways for colouration;(iii) how to fixate the bacterial colonies while retaining their optical properties.We have identified a wide range of methods to reversibly and irreversibly change organisation (and hence colour) of the living colonies through growth conditions and many types of external stimuli. The studentship will use our well-established characterisation methods and knowledge to explore how this bacterial system can be modified towards controlled photonic applications. This will involve a wide range of traditional microbiology tools ranging from screening of growth conditions to DNA genetics via CRISPR.

该项目的首要目标是研究和利用一种新型黄杆菌（菌株IR 1）菌落的光子特性，该菌落自组装成光子晶体。该菌株是一种直径约400纳米的杆状海洋细菌，以紧密的六边形晶格聚集在菌落中。菌落呈现明亮、闪烁的绿色，因为可见光谱的一部分被该组织强烈反射。这种效应可以用光子晶体理论来描述，并且不涉及色素沉着。我们特别希望了解：（i）光散射与结构组织的关系（周期性，规律性），使我们可以筛选他们的光学;（ii）基因改造如何改变光学特性，并揭示重要的遗传途径的着色;（iii）如何固定细菌菌落，同时保持其光学特性。我们已经确定了一系列可逆和不可逆改变组织的方法通过生长条件和许多类型的外部刺激，可以改变活菌落的颜色。学生将使用我们完善的表征方法和知识来探索如何将这种细菌系统改造成受控的光子应用。这将涉及广泛的传统微生物学工具，从筛选生长条件到通过CRISPR进行DNA遗传学。