EMBRYONIC DEVELOPMENT OF THE EFFERENT SYSTEM

传出系统的胚胎发育

• 批准号: 6564033
• 负责人: BERND FRITZSCH
• 金额: $ 26.25万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564033
• 关键词: axon; cell migration; chick embryo; developmental neurobiology; efferent nerve; fluorescent dye /probe; gene expression; innervation; laboratory mouse; motor neurons; neuroanatomy; neurogenesis; neuronal guidance; neurotrophic factors; vertebrate embryology

The efferent motoneuron system that projects to the ear develops in mice and chicken out of the facial branchial motor primordium. Like other motor systems, the efferent cells will likely depend for their survival on unknown, neurotrophic factor(s) available at their target. In addition, various conditions such as the time of arrival and the size of the target area innervated have been suggested to play a role in the survival of motoneurons. This project seeks to test this notion by quantifying the numbers of efferents projecting to the ear over time. We will use certain features unique to the efferent system to explore issues of timing of arrival and target size which is different in the various subpopulations of efferents, and which cannot be investigated in any other motor system. We will also explore mutants with variable reductions of both the afferent and efferent innervation to certain sensory epithelia or reduction of the ear, including surgical removal, to analyze further the quantitative relationship between the developing ear and the developing efferents. Our experiments will also provide insights into the possibly limited availability of trophic support only at the otocyst by testing the survival of efferent cells rerouted to a non-otic target in chickens. Together this information will provide baseline data that can help to find clues for interventive measures in patients with loss of hair cells to prevent loss of efferents.

向耳朵发育的发出的运动神经元系统在老鼠中发展 和鸡肉从面部分支运动原始物中出来。 像其他 电机系统，传出细胞可能取决于其生存 关于未知的神经营养因子在其靶标上可用。 在 此外，各种条件，例如到达时间和大小 已经建议在目标区域中发挥作用 运动神经元的生存。 该项目旨在通过 随着时间的推移，量化投射到耳朵的传出数量。 我们将使用Efferent系统独特的某些功能来探索 到达时间和目标大小的问题，这在 传出的各种亚群，无法研究 在任何其他电机系统中。 我们还将探索变量的突变体 将传入和传出的神经支配减少到某些 感觉上皮或耳朵还原，包括手术去除， 进一步分析开发之间的定量关系 耳朵和发展中的传出。 我们的实验也将提供 洞悉可能有限的营养支持可用性 通过测试被重新路由到A 鸡的非色调靶标。 这些信息将共同提供 基线数据，可以帮助找到有关干预措施的线索 毛细胞损失的患者可以防止流失。