Functional Senescence in Drosophila

我的实验室目前由NIMH和其他来源资助，研究果蝇记忆的分子基础，但我以前没有接受过对衰老研究的校外支持。因此，我是一个成熟的调查员进入衰老研究。通过更好地理解功能性衰老的分子基础，将大大促进旨在改善与年龄相关的功能下降的治疗。本项目将探讨果蝇寿命控制和功能性衰老之间的遗传关系。此外，该项目将在果蝇中使用强大的遗传工具来探索功能性衰老的分子基础。总之，这些研究将为神经系统功能中与年龄相关的变化提供更多信息。

My laboratory is currently funded by NIMH and other sources to study the molecular bases of memory in Drosophila, but I have not previously received extramural support for studies on aging. Thus, I am an established investigator moving into aging research. Therapies aimed at ameliorating age-related functional declines would be greatly facilitated by a better understanding of the molecular bases of functional senescence. This project will explore the genetic relationship between control of longevity and functional senescence in Drosophila. Additionally, this project will use powerful genetic tools in Drosophila to explore the molecular underpinnings of functional senescence. Together, these studies will shed much light on age-related changes in nervous system function.