Genetic Dissection of Locomotor Senescence in Drosophila

果蝇运动衰老的遗传解析

• 批准号: 7094485
• 负责人: MICHAEL S. GROTEWIEL
• 金额: $ 18.33万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7094485
• 关键词: Drosophilidae; aging; arthropod genetics; bioassay; diet; flying; functional ability; gene targeting; genetic mapping; genetically modified animals; high throughput technology; longevity; olfactions; polymerase chain reaction; reproduction; stress management; thermoreception; transposon /insertion element

DESCRIPTION (provided by applicant): The long-term goal of this project is to understand the genetic pathways that influence functional senescence using the fruit fly, Drosophila melanogaster, as a model. Although a number of genes involved in life span determination have been identified, our understanding of genes that regulate age-related functional declines is limited. Thus, the processes that govern health span remain largely uncharacterized. During the proposed funding period, my laboratory will pursue the molecular mechanisms underlying altered functional senescence in a series of recently identified Drosophila mutants. We will also begin a systematic exploration of mechanistic connections between control of life span and control of health span. These studies will help us to understand the molecular processes that underlie functional senescence and potentially life span determination. These studies will help determine how we age. They should lead to information that will help us reduce the negative effects of aging in people.

描述(申请人提供)：该项目的长期目标是以果蝇为模型，了解影响功能性衰老的遗传途径。尽管已经确定了一些与寿命决定有关的基因，但我们对调节与年龄相关的功能衰退的基因的了解有限。因此，管理健康跨度的过程在很大程度上仍未确定。在拟议的资助期内，我的实验室将探索最近发现的一系列果蝇突变体功能衰老改变的分子机制。我们还将开始系统地探索控制寿命和控制健康寿命之间的机械联系。这些研究将帮助我们理解决定功能衰老和潜在寿命的分子过程。这些研究将有助于确定我们的年龄。它们应该带来一些信息，帮助我们减少老龄化对人类的负面影响。