Epigenetic regulation of cell lineage differentiation in the early embryo

早期胚胎细胞谱系分化的表观遗传调控

• 批准号: nhmrc : GNT1103991
• 负责人: Prof Christopher O'Neill
• 金额: $ 44.1万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-cell-early-embryo/1346322
• 关键词: Epigenetic; regulation; cell; lineage; differentiation

Exposure of embryos to a range of stresses can increase the predisposition to chronic diseases of adulthood. Stressing embryos at critical stages of development cause errors in reorganization of the nucleus that are required for normal gene expression. These errors are propagated into adulthood. This project will map the normal processes of nuclear reorganization and define how stress to the embryo changes this process, allowing an understanding of the causes of some important chronic diseases.

胚胎暴露在一系列压力下会增加成年后患慢性疾病的倾向。在发育关键阶段对胚胎施加压力会导致正常基因表达所需的细胞核重组出现错误。这些错误会传播到成年期。该项目将绘制核重组的正常过程，并定义胚胎的压力如何改变这一过程，从而了解一些重要慢性疾病的原因。