Long term consequences of perturbing early embryo development

扰乱早期胚胎发育的长期后果

• 批准号: nhmrc : 1004177
• 负责人: Prof Christopher O'Neill
• 金额: $ 36.64万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/long-term-consequences-embryo-development/109012
• 关键词: Long; term; consequences; perturbing; early

Assisted reproductive techniques are normally considered safe, but there are increased risks for these newborns which may be caused by these procedures. We have developed mouse models that are sensitive to these effects and have used them to show that gene expression is altered in mice that develop from cultured embryos. Now we will use these models to work out how to reduce these effects and ensure the ongoing health of babies born with assisted reproduction.

辅助生殖技术通常被认为是安全的，但这些程序可能会增加这些新生儿的风险。我们已经开发出对这些效应敏感的小鼠模型，并使用它们来显示从培养胚胎发育的小鼠中基因表达的改变。现在，我们将使用这些模型来研究如何减少这些影响，并确保辅助生殖婴儿的持续健康。