The role of transcription factors in regulating the first round of gene expression in the early embryo.

转录因子在调节早期胚胎第一轮基因表达中的作用。

• 批准号: nhmrc : 512136
• 负责人: Prof Christopher O'Neill
• 金额: $ 23.27万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-transcription-factors-early-embryo/96811
• 关键词: role; transcription; factors; regulating; first

Assisted reproductive technologies result in a high incidence of multiple births. This is and adverse outcome that requires correction. It stems from the common transfer of several embryos due to the low chance of an individual embryo made by IVF resulting in a baby. This project will determine the normal pattern of gene expression in the embryo and define: (1) how it is adversely changed as a consequence of IVF; and (2) the extent that these changes are a cause of the low embryo viability.

辅助生殖技术导致多胞胎的高发生率。这是一个需要纠正的不良后果。由于试管受精产生的单个胚胎产生婴儿的可能性很低，因此通常会移植几个胚胎。该项目将确定胚胎中基因表达的正常模式，并定义：(1)体外受精如何对其产生不利影响；(2)这些变化是导致胚胎存活率低的原因。