Mechanisms of p53 induced embryopathy after in vitro fertilisation.

p53 诱导体外受精后胚胎病的机制。

• 批准号: nhmrc : 512137
• 负责人: Prof Christopher O'Neill
• 金额: $ 32.26万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-p53-induced-vitro-fertilisation/81997
• 关键词: Mechanisms; p53; induced; embryopathy; after

Assisted reproductive technologies (ART) cause many embryos not to survive to birth. We have shown that IVF causes increased expression of protein normally involved in stopping cells from dividing. This is a major cause of embryo death after IVF. This project will determine how this protein acts to cause embryonic death and assess strategies to prevent it.

辅助生殖技术(ART)导致许多胚胎不能存活到出生。我们已经证明，试管受精会导致正常情况下与阻止细胞分裂有关的蛋白质表达增加。这是试管受精后胚胎死亡的主要原因。该项目将确定这种蛋白质如何导致胚胎死亡，并评估预防策略。