Harnessing innate immunity to combat microbial infection: The case of STAT transcription factors

利用先天免疫对抗微生物感染：STAT 转录因子的案例

• 批准号: 2116004
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2116004
• 关键词: Harnessing; innate; immunity; combat; microbial

This PhD project is based on our recent discovery of a new mechanism by which STAT transcription factors function in the mammalian immune system. We are planning to translate the findings to avian immunity. The student will characterise the molecular details of the new-found mechanism in chicken STAT proteins and explore how they contribute to host defence against intracellular bacteria and viruses. We will use recombinant proteins, mass spectrometry, and other cutting edge biochemical and biophysical methods to identify critical protein interactions that regulate STAT protein functioning in the innate immune system of this economically important bird.

这个博士项目是基于我们最近发现的一种新的机制，通过这种机制，STAT转录因子在哺乳动物免疫系统中发挥作用。我们正计划将这些发现转化为禽类免疫力。学生将描述在鸡STAT蛋白中新发现的机制的分子细节，并探索它们如何有助于宿主防御细胞内细菌和病毒。我们将使用重组蛋白、质谱学和其他尖端的生化和生物物理方法来确定调节这种经济重要鸟类先天免疫系统中STAT蛋白功能的关键蛋白质相互作用。