Epigenetic regulation of male fetal germ cell development.

男性胎儿生殖细胞发育的表观遗传调控。

• 批准号: nhmrc : 1043939
• 负责人: Dr Patrick Western
• 金额: $ 37.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-male-cell-development/111616
• 关键词: Epigenetic; regulation; male; fetal; germ

Men’s health has declined over recent decades, but the causes remain unknown. Non-genetic (epigenetic) mechanisms affecting formation and function of the male germ cells (which produce sperm) may play an important role. We will determine the role of a key epigenetic modifier on the formation and function of male germ cells, including germ cell tumours. This study will provide fundamental insights into male germ cell epigenetics, and significantly contribute to understanding men's health.

近几十年来，男性的健康状况有所下降，但原因尚不清楚。影响男性生殖细胞（产生精子）形成和功能的非遗传（表观遗传）机制可能起重要作用。我们将确定一个关键的表观遗传修饰在男性生殖细胞，包括生殖细胞肿瘤的形成和功能中的作用。该研究将为男性生殖细胞表观遗传学提供基础见解，并对了解男性健康具有重要意义。