Defining the epigenetic origins of maternally inherited disease.

定义母系遗传疾病的表观遗传起源。

• 批准号: nhmrc : GNT1144966
• 负责人: Dr Patrick Western
• 金额: $ 73.12万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-epigenetic-origins-inherited-disease/1348651
• 关键词: Defining; epigenetic; origins; maternally; inherited

Epigenetic (non genetic) changes to the DNA in sperm and eggs can alter outcomes in children. Despite the potential for drugs and diet to mediate some of these inherited effects, the processes involved are very poorly understood. By determining the mechanisms that regulate epigenetic inheritance, this project will improve our understanding of how epigenetic mechanisms acting in the parent, can mediate inherited disease and life-long health outcomes in our children.

精子和卵子中DNA的表观遗传（非遗传）变化可以改变儿童的结果。尽管药物和饮食有可能介导这些遗传效应，但对所涉及的过程知之甚少。通过确定调节表观遗传的机制，该项目将提高我们对表观遗传机制如何在父母中起作用的理解，可以介导我们孩子的遗传性疾病和终身健康结果。