Activin Control of the Male Germline for Reproductive Health

激活素控制男性生殖系的生殖健康

• 批准号: nhmrc : 1081987
• 负责人: Dr Patrick Western
• 金额: $ 61.06万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activin-control-male-reproductive-health/518845
• 关键词: Activin; Control; Male; Germline; Reproductive

The growth factor activin provides key signals in embryonic and infant testes to coordinate development of male germline cells into sperm. This project tests how activin controls genetic stability when the human testis is vulnerable to forming germline cells that become tumours in young men. We will study how activin acts to allow sperm stem cells to multiply and develop in sufficient numbers for adult fertility.

生长因子激活素在胚胎和婴儿睾丸中提供关键信号，以协调雄性生殖细胞发育成精子。该项目测试了当人类睾丸容易形成生殖细胞并在年轻男性中成为肿瘤时，激活素如何控制遗传稳定性。我们将研究激活素如何作用，使精子干细胞繁殖和发展，在成年生育能力足够的数量。