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Metabonomic Urine Analysis: The INTERMAP Diet-BP Study

尿液代谢分析：INTERMAP 饮食-血压研究

基本信息

批准号：
6662605
负责人：
JEREMIAH STAMLER
金额：
$ 10.48万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2005-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6662605
关键词：
blood pressure cardiovascular disorder epidemiology cardiovascular disorder risk clinical research diet high performance liquid chromatography human data human tissue hypertension magnetic resonance imaging metabolism nutrition related tag racial /ethnic difference urinalysis

项目摘要

DESCRIPTION (provided by applicant): INTERMAP is a basic epidemiologic investigation that aims to clarify unanswered questions on the role of dietary factors, particularly macronutrients (total, animal and vegetable protein, individual amino acids, fatty acids, cholesterol, sugars), also micronutrients, in the etiology of unfavorable blood pressure (BP) patterns prevailing for most middle-aged and older individuals. Supported by NHLBI, ten primary hypotheses, four subgroup hypotheses and multiple exploratory questions on diet and BP are being addressed by means of a high-quality international cooperative 17-sample population study of 4,680 men and women ages 40-59 from four countries (China, Japan, UK, US) - of varied ethnic-racial and socio-demographic backgrounds - consuming diverse diets. These analyses use extensive data on nutrient intake for all 4,680 participants, generated from four 24-hour recalls and the 4 country databases (developed by INTERMAP) on nutrient composition of all reported foods (with data on 71 nutrients), and from two 24-hr urine collections (already analyzed) on Na, K, Ca, Mg, urea, creatinine, volume and microalbuminuria. Further NHLBI-funded research in progress includes analysis of urinary amino acids of each individual, and coding of reported dietary supplements. New work proposed here is novel, exploratory, knowledge generating and "pre-competitive" in nature, in keeping with the aims of this RFA. It involves a) application of novel biochemical (metabonomic) techniques i.e., high field Nuclear Magnetic Resonance (NMR) spectroscopy and HPLC for elucidation of metabolic patterns and constituents in all INTERMAP urinary samples, and b) analyses of relations of these urinary metabolic patterns/constituents to nutrient intakes and BP of individuals. It offers a unique opportunity to make substantive nutritional-metabolic-BP links between INTERMAP dietary recall and urine data, multiple metabolic characteristics from urinary NMR analyses, and 8 measurements of SBP/DBP - links not available on populations from any other research. The NMR data are also meaningful "in their own right" to gain knowledge for the first time on urinary metabolic excretion patterns in diverse, free-living populations. The research involves new collaboration of senior INTERMAP investigators (Chicago, London) with the Center for Metabonomic Research, Imperial College, London, a world-leader in high-throughput NMR measurement of biofluids.

描述（由申请人提供）： INTERMAP 是一项基本的流行病学调查，旨在澄清饮食因素，特别是常量营养素（总的动植物蛋白、个别氨基酸、脂肪酸、胆固醇、糖）以及微量营养素在大多数中老年人普遍存在的不良血压（BP）模式的病因学中的作用，这些问题尚未得到解答。在 NHLBI 的支持下，关于饮食和血压的 10 个主要假设、4 个亚组假设和多个探索性问题正在通过一项高质量的国际合作性 17 个样本人群研究得到解决，该研究涉及来自四个国家（中国、日本、英国、美国）的 4,680 名 40-59 岁的男性和女性，他们具有不同的民族、种族和社会人口背景，饮食多样化。这些分析使用了所有 4,680 名参与者的营养摄入量的广泛数据，这些数据来自四次 24 小时召回和 4 个国家数据库（由 INTERMAP 开发）关于所有报告食物的营养成分（包含 71 种营养素的数据），以及两次 24 小时尿液收集（已分析）中的钠、钾、钙、镁、尿素、肌酸酐、体积和微量白蛋白尿。 NHLBI 资助的进一步研究正在进行中，包括分析每个人的尿氨基酸以及对报告的膳食补充剂进行编码。这里提出的新工作具有新颖性、探索性、知识生成性和“竞争前”性质，符合本 RFA 的目标。它涉及 a) 应用新型生化（代谢组学）技术，即高场核磁共振 (NMR) 波谱和 HPLC 来阐明所有 INTERMAP 尿液样本中的代谢模式和成分，以及 b) 分析这些尿液代谢模式/成分与个体营养摄入和血压的关系。它提供了一个独特的机会，可以在 INTERMAP 饮食回忆和尿液数据、尿液 NMR 分析的多种代谢特征以及 SBP/DBP 的 8 项测量之间建立实质性的营养-代谢-血压联系，这是任何其他研究中无法在人群上获得的联系。核磁共振数据“本身”也很有意义，可以首次了解不同自由生活人群的尿液代谢排泄模式。该研究涉及 INTERMAP 高级研究人员（芝加哥、伦敦）与伦敦帝国理工学院代谢组学研究中心的新合作，该中心是生物流体高通量 NMR 测量领域的世界领先者。