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Metabonomic Urine Analysis: The INTERMAP Diet-BP Study

尿液代谢分析：INTERMAP 饮食-血压研究

基本信息

批准号：
6662605
负责人：
JEREMIAH STAMLER
金额：
$ 10.48万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2005-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6662605
关键词：
blood pressure cardiovascular disorder epidemiology cardiovascular disorder risk clinical research diet high performance liquid chromatography human data human tissue hypertension magnetic resonance imaging metabolism nutrition related tag racial /ethnic difference urinalysis

项目摘要

DESCRIPTION (provided by applicant): INTERMAP is a basic epidemiologic investigation that aims to clarify unanswered questions on the role of dietary factors, particularly macronutrients (total, animal and vegetable protein, individual amino acids, fatty acids, cholesterol, sugars), also micronutrients, in the etiology of unfavorable blood pressure (BP) patterns prevailing for most middle-aged and older individuals. Supported by NHLBI, ten primary hypotheses, four subgroup hypotheses and multiple exploratory questions on diet and BP are being addressed by means of a high-quality international cooperative 17-sample population study of 4,680 men and women ages 40-59 from four countries (China, Japan, UK, US) - of varied ethnic-racial and socio-demographic backgrounds - consuming diverse diets. These analyses use extensive data on nutrient intake for all 4,680 participants, generated from four 24-hour recalls and the 4 country databases (developed by INTERMAP) on nutrient composition of all reported foods (with data on 71 nutrients), and from two 24-hr urine collections (already analyzed) on Na, K, Ca, Mg, urea, creatinine, volume and microalbuminuria. Further NHLBI-funded research in progress includes analysis of urinary amino acids of each individual, and coding of reported dietary supplements. New work proposed here is novel, exploratory, knowledge generating and "pre-competitive" in nature, in keeping with the aims of this RFA. It involves a) application of novel biochemical (metabonomic) techniques i.e., high field Nuclear Magnetic Resonance (NMR) spectroscopy and HPLC for elucidation of metabolic patterns and constituents in all INTERMAP urinary samples, and b) analyses of relations of these urinary metabolic patterns/constituents to nutrient intakes and BP of individuals. It offers a unique opportunity to make substantive nutritional-metabolic-BP links between INTERMAP dietary recall and urine data, multiple metabolic characteristics from urinary NMR analyses, and 8 measurements of SBP/DBP - links not available on populations from any other research. The NMR data are also meaningful "in their own right" to gain knowledge for the first time on urinary metabolic excretion patterns in diverse, free-living populations. The research involves new collaboration of senior INTERMAP investigators (Chicago, London) with the Center for Metabonomic Research, Imperial College, London, a world-leader in high-throughput NMR measurement of biofluids.

描述（由申请人提供）： INTERMAP是一项基本的流行病学调查，旨在澄清饮食因素的作用，特别是大量营养素（总蛋白、动物蛋白和植物蛋白、单个氨基酸、脂肪酸、胆固醇、糖）以及微量营养素在大多数中年和老年人普遍存在的不良血压（BP）模式病因学中的作用。在NHLBI的支持下，通过一项高质量的国际合作17样本人群研究，对来自四个国家（中国，日本，英国，美国）的4，680名年龄在40 - 59岁之间的男性和女性进行了10个主要假设，4个亚组假设和多个关于饮食和BP的探索性问题-不同的种族和社会人口背景-消费不同的饮食。这些分析使用了所有4，680名参与者的营养素摄入量的广泛数据，这些数据来自4次24小时召回和4个国家数据库（由INTERMAP开发），涉及所有报告食物的营养成分（71种营养素的数据），以及两次24小时尿液采集（已分析），涉及Na，K，Ca，Mg，尿素，肌酐，体积和微量白蛋白尿。NHLBI资助的进一步研究正在进行中，包括分析每个人的尿液氨基酸，以及对报告的膳食补充剂进行编码。这里提出的新工作是新颖的，探索性的，知识产生和“竞争前”的性质，在保持与本RFA的目标。它涉及a）新的生物化学（代谢组学）技术的应用，即，高场核磁共振（NMR）光谱和HPLC，用于阐明所有INTERMAP尿样中的代谢模式和成分，和B）分析这些尿代谢模式/成分与个体的营养摄入和BP的关系。它提供了一个独特的机会，使INTERMAP饮食回忆和尿液数据之间的实质性营养-代谢-BP联系，尿NMR分析的多种代谢特征，以及8个SBP/DBP测量值-任何其他研究的人群中没有的联系。核磁共振数据也是有意义的“在自己的权利”，以获得知识的第一次在不同的，自由生活的人群的尿代谢排泄模式。该研究涉及INTERMAP高级研究人员（芝加哥，伦敦）与伦敦帝国理工学院代谢组学研究中心的新合作，该中心是生物流体高通量NMR测量的世界领先者。