Cognitive Processes, PTSD, and Alcohol Use

认知过程、创伤后应激障碍和饮酒

• 批准号: 6739184
• 负责人: DEBRA L KAYSEN
• 金额: $ 4.36万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6739184
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; behavior prediction; behavioral /social science research tag; clinical research; cognition; comorbidity; expectancy; female; human subject; postdoctoral investigator; posttraumatic stress disorder; self medication; sex abuse; violence

DESCRIPTION (provided by applicant): Co-morbid PTSD and alcohol use disorders are both common and debilitating, therefore, identification of factors related to their development is of great import. Research findings support a self-medication hypothesis to explain this comorbidity. Yet mechanisms explaining the use of alcohol for self-medication of PTSD remain unaddressed. The overarching purpose of this study is to examine a cognitive model of AUD following traumatic events. This model will integrate cognitive processing theory of PTSD with models for the development of AUD emphasizing cognitive expectancies. This study will use a longitudinal design, assessing 100 adult women with a physical or sexual assault one, three, and six months after the traumatic event to determine how AUD develop over time, as a function of general and PTSD-specific alcohol outcome expectancies, cognitions affected by the traumatic event, and severity of PTSD symptoms. Aim 1: Examine general alcohol expectancies 1 month post-trauma, as predictors of alcohol consumption, and PTSD-specific alcohol expectancies 3 months post-trauma. Aim 2: Examine PTSD severity I month post-trauma, as a predictor of alcohol consumption and PTSD-specific alcohol expectancies 3 months post-trauma. Aim 3: Evaluate assimilation and over-accommodation I month post-trauma as predictors of PTSD symptoms 3 months post-trauma. Aim 4: Evaluate alcohol consumption, PTSD-specific alcohol expectancies, and PTSD severity 3 months post-trauma as predictors of alcohol use disorders 6 months post-trauma.

描述（由申请人提供）：共病创伤后应激障碍（PTSD）和酒精使用障碍都很常见，而且使人衰弱，因此，确定与其发展相关的因素非常重要。研究结果支持自我药疗假说来解释这种合并症。然而，解释使用酒精自我治疗创伤后应激障碍的机制仍未得到解决。本研究的首要目的是检查创伤事件后 AUD 的认知模型。该模型将 PTSD 的认知处理理论与强调认知预期的 AUD 发展模型相结合。这项研究将采用纵向设计，评估 100 名在创伤事件发生后 1、3 和 6 个月遭受身体或性侵犯的成年女性，以确定 AUD 如何随着时间的推移而发展，作为一般和 PTSD 特定酒精结果预期、受创伤事件影响的认知以及 PTSD 症状严重程度的函数。目标 1：检查创伤后 1 个月的一般饮酒预期（作为饮酒量的预测因素）以及创伤后 3 个月的 PTSD 特定饮酒预期。目标 2：检查创伤后 1 个月的 PTSD 严重程度，作为创伤后 3 个月饮酒量和 PTSD 特定饮酒预期的预测指标。目标 3：评估创伤后 1 个月的同化和过度适应，作为创伤后 3 个月 PTSD 症状的预测因子。目标 4：评估创伤后 3 个月的饮酒量、PTSD 特定的酒精预期和 PTSD 严重程度，作为创伤后 6 个月酒精使用障碍的预测因子。