BREAST CANCER: DEMONSTRATION OF FREQUENCY DOMAIN DIFFUSIVE EMISSION TOMOGRAPHY

乳腺癌：频域扩散发射断层扫描演示

• 批准号: 6657653
• 负责人: JOHN C SCHOTLAND
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657653
• 关键词: bioimaging /biomedical imaging; biomedical resource; microscopy; technology /technique

Recently it has become appreciated that near-field optical methods may be used to develop a new form of microscopy with the remarkable feature of subwavelength spatial resolution. The images obtained with such near-field methods, however, are difficult to interpret and are not related in an obvious way to the structure of the sample under study. For this reason, there is substantial interest in developing a solution to the inverse scattering problem in the near field. It turns out that this problem may be solved by an approach which is closely related to that used for solving the inverse problem in diffusion imaging. The connection between these problems arises from a deep analogy between diffusing waves and evanescent waves, since the latter carries information about subwavelength length scales. By exploiting this analogy, we have developed an analytic inverse-scattering procedure that may be used to reconstruct the index of refraction from near-field scattering data. Exp erimental validation of this method is in progress and promises to allow the visualization of molecular detail with light microscopy.

最近，人们已经认识到，近场光学方法 可以用来开发一种新的显微镜形式， 具有亚波长空间分辨率的特点。 获得的图像， 然而，这种近场方法难以解释， 与样品的结构没有明显的关系， study. 因此，人们对开发一种 近场逆散射问题的求解。 它 事实证明，这个问题可以通过一种方法来解决， 与用于解决反问题的方法密切相关， 扩散成像 这些问题之间的联系源于 扩散波和倏逝波之间的深刻类比，因为 后者携带关于亚波长长度尺度的信息。 通过 利用这个类比，我们已经开发了一个分析 可用于重建折射率的逆散射过程 折射的近场散射数据。 实验室 这种方法的验证正在进行中，并承诺允许 用光学显微镜观察分子细节。