Large Database Research for Cancer Prevention & Control

候选人是一名胃肠病学家/健康服务研究人员，主要通过使用基于人口的大型数据库，开发了癌症预防和控制的重点研究项目。此外，他还指导了几名不同级别的培训学员和初级教师。然而，由于时间和预算的限制，他为初级研究人员提供数据和方法支持的能力越来越有限。此外，他一直无法将他的研究重点扩展到不同的癌症部位和其他内容领域，包括药物流行病学。拟议的癌症预防、控制、行为和人口研究建立研究者奖将帮助候选人实现他的长期职业目标。其中包括评估常规临床实践中常用的筛查、治疗和监测程序的有效性；确定衡量癌症筛查、监测和治疗的替代方法的准确性、完整性和适宜性；培养大量的癌症预防和控制研究人员。该提案将使候选人能够使用具有丰富经验的数据源来研究其他临床相关问题。他将研究食管恶性前病变的识别及其对患者预后的影响，以及内镜超声检查在胃肠道肿瘤患者诊断和治疗中的使用频率和临床影响。此外，我们将开发使用药学数据库的专业知识，以研究非甾体抗炎药对结直肠癌发病率的保护作用。该奖项的资源还将使目标能够发展一种基础设施，提供必要的数据和研究支持，培训初级调查人员使用大型数据库进行与癌症有关的保健服务研究。

The Candidate, a gastroenterologist/health services researcher has developed a focused research program in cancer prevention and control, primarily through the use of large population-based databases. In addition, he has mentored several trainees and junior faculty at different levels of training. However, because of time and budgetary restraints, his ability to provide data and methodological support to junior researchers is increasingly limited. In addition, he has been unable to expand his research focus to different cancer sites and other content areas, including pharmacoepidemiology. The proposed Established Investigator Award in Cancer Prevention, Control Behavioral and Population Research will assist the Candidate in fulfilling his long-term career goals. These include to evaluate the effectiveness of commonly performed screening, treatment and surveillance procedures in routine clinical practice; determine the accuracy, completeness and appropriateness of alternative methods to measure cancer screening, surveillance, and therapy; and develop a critical mass of cancer prevention and control researchers. The proposal will enable the Candidate to use data sources with which has considerable experience to study other clinically relevant issues. He will investigate the recognition of pre-malignant conditions of the esophagus and its impact on patient outcome, as well as the frequency of use and clinical impact of endoscopic ultrasonography on the diagnosis and treatment of patients with gastrointestinal cancer. In addition, we will develop expertise in the use of pharmacy databases to study the protective effects of non-steroidal anti-inflammatory drugs on colorectal cancer incidence. The resources of this award will also enable aim to develop an infrastructure that will provide the necessary data and research support to train junior investigators in the use of large databases to conduct cancer related health services research.