Large Database Research for Cancer Prevention & Control

这位候选人是一名胃肠病专家/卫生服务研究员，他主要通过使用基于人群的大型数据库，在癌症预防和控制方面制定了一个重点研究计划。此外，他还指导了几名不同级别培训的实习生和初级教职员工。然而，由于时间和预算的限制，他向初级研究人员提供数据和方法支持的能力越来越有限。此外，他一直无法将研究重点扩大到不同的癌症网站和其他内容领域，包括药物流行病学。拟议设立的癌症预防、控制行为和人口研究研究员奖将帮助候选人实现其长期职业目标。这些措施包括评估常规临床实践中常用的筛查、治疗和监测程序的有效性；确定衡量癌症筛查、监测和治疗的替代方法的准确性、完整性和适当性；以及培养一支癌症预防和控制研究人员队伍。该提案将使候选人能够使用具有相当经验的数据源来研究其他临床相关问题。他将调查对食道癌前状况的认识及其对患者预后的影响，以及内窥镜超声在胃肠癌患者诊断和治疗中的使用频率和临床影响。此外，我们将利用药学数据库发展专门知识，研究非类固醇抗炎药对结直肠癌发病率的保护作用。这项奖励的资源还将使AIM能够开发一个基础设施，提供必要的数据和研究支持，以培训初级调查人员使用大型数据库进行与癌症相关的卫生服务研究。

The Candidate, a gastroenterologist/health services researcher has developed a focused research program in cancer prevention and control, primarily through the use of large population-based databases. In addition, he has mentored several trainees and junior faculty at different levels of training. However, because of time and budgetary restraints, his ability to provide data and methodological support to junior researchers is increasingly limited. In addition, he has been unable to expand his research focus to different cancer sites and other content areas, including pharmacoepidemiology. The proposed Established Investigator Award in Cancer Prevention, Control Behavioral and Population Research will assist the Candidate in fulfilling his long-term career goals. These include to evaluate the effectiveness of commonly performed screening, treatment and surveillance procedures in routine clinical practice; determine the accuracy, completeness and appropriateness of alternative methods to measure cancer screening, surveillance, and therapy; and develop a critical mass of cancer prevention and control researchers. The proposal will enable the Candidate to use data sources with which has considerable experience to study other clinically relevant issues. He will investigate the recognition of pre-malignant conditions of the esophagus and its impact on patient outcome, as well as the frequency of use and clinical impact of endoscopic ultrasonography on the diagnosis and treatment of patients with gastrointestinal cancer. In addition, we will develop expertise in the use of pharmacy databases to study the protective effects of non-steroidal anti-inflammatory drugs on colorectal cancer incidence. The resources of this award will also enable aim to develop an infrastructure that will provide the necessary data and research support to train junior investigators in the use of large databases to conduct cancer related health services research.