Epistatic genetic effects on neuroanatomical subtypes of schizophrenia

上位遗传对精神分裂症神经解剖亚型的影响

• 批准号: nhmrc : 1051672
• 负责人: A/Pr Kristin Laurens
• 金额: $ 27.35万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epistatic-genetic-effects-subtypes-schizophrenia/112231
• 关键词: Epistatic; genetic; effects; neuroanatomical; subtypes

Schizophrenia represents a number of clinically distinct syndromes, with a complex mode of inheritance. The delineation of biologically valid subtypes of schizophrenia is necessary to advance our understanding of the genetic basis of these syndromes. This project uses pattern classification techniques to determine subtypes of schizophrenia on the basis of structural brain abnormality across multiple regions, and will examine genetic interactions and differential gene expression associated with these biologically-derived subtypes.

精神分裂症代表了一些临床不同的综合征，具有复杂的遗传模式。生物学上有效的精神分裂症亚型的描述是必要的，以促进我们对这些综合征的遗传基础的理解。本项目利用模式分类技术，以跨多个区域的脑结构异常为基础，确定精神分裂症的亚型，并将研究与这些生物学衍生亚型相关的遗传相互作用和差异基因表达。