THE ROLE OF CO-MORBID MENTAL DISORDERS IN LYME DISEASE

共病精神障碍在莱姆病中的作用

• 批准号: 6622827
• 负责人: Afton L Hassett
• 金额: $ 12.63万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6622827
• 关键词: Lyme disease; behavioral /social science research tag; comorbidity; disease /disorder proneness /risk; human subject; longitudinal human study; mental disorders; pathologic process; patient oriented research; postdoctoral investigator; psychosomatic disorders; questionnaires

DESCRIPTION (provided by investigator): Committed to a career in behavioral science research, the candidate's immediate goals are to obtain high quality didactic training and additional mentored experience related to interdisciplinary research. Long term career goals include exploring the role of co-morbid mental disorders and related psychological processes in rheumatologic illness and eventually becoming an expert on medically unexplained symptom syndromes across specialties. Current research is based on the candidate's stress-diathesis theoretical model for the "psychopathogenesis" of unexplained symptom syndromes present in rheumatology, i.e., Post Lyme Disease and fibromyalgia. The K08 Award would allow the candidate to devote 80 percent of her time to research and training. UMDNJ-Robert Wood Johnson Medical School is an outstanding environment in which to conduct this type of research. In addition to traditional biomedical research, many faculty members are actively exploring the role of psychological processes in health and illness. Mentorship would be provided by two such exceptional faculty, Javier I. Escobar, MD, Chairman of Psychiatry and Leonard H. Sigal MD, Chief of Rheumatology and Director of the Lyme Disease Center at UMDNJ-RWJMS. In addition to superior mentored clinical research experience, the candidate will receive advanced training in research methodology, statistical analysis, the responsible conduct of research, and neuroscience. Training highlights include statistical analyses through the Department of Statistics at Rutgers University and Neuroscience coursework at Princeton University. Mentored experience in research will consist of two studies. Study 1 will assess the co-morbid clinical disorders (Axis I) and pathological personality traits (Axis II) of patients who attribute chronic symptoms to Lyme disease. Study 2 prospectively examines newly diagnosed Lyme disease patients for co-morbid mental disorders and related cognitive/behavioral processes at baseline and follows them for one year. Our goal is to identify risk factors for the development of chronic symptoms ascribed to Lyme disease after adequate antibiotic treatment.

描述（由研究者提供）：致力于行为领域的职业 科学研究，候选人的直接目标是获得高质量 相关的教学培训和额外的指导经验 跨学科研究。长期职业目标包括探索角色 共病精神障碍和相关心理过程的研究 风湿病并最终成为医学专家 跨专业的无法解释的症状综合症。目前的研究基于 候选人的“心理发病机制”的压力素质理论模型 风湿病中存在的无法解释的症状综合征，即莱姆病后 疾病和纤维肌痛。 K08 奖将允许候选人投入 80 她将 10% 的时间用于研究和培训。 UMDNJ-罗伯特·伍德·约翰逊医疗中心 学校是进行此类研究的绝佳环境。 除了传统的生物医学研究之外，许多教职人员还从事 积极探索心理过程在健康和疾病中的作用。 导师将由两位杰出的教师提供，哈维尔一世 (Javier I. Escobar 医学博士、精神病学主席和 Leonard H. Sigal 医学博士、精神病学主任 UMDNJ-RWJMS 风湿病学兼莱姆病中心主任。在 除了卓越的指导临床研究经验外，候选人还将 接受研究方法、统计分析、 负责任的研究行为和神经科学。培训亮点包括 通过罗格斯大学统计系进行统计分析 和普林斯顿大学的神经科学课程。指导经验 研究将包括两项研究。研究 1 将评估共病 临床障碍（轴 I）和病理性人格特征（轴 II） 将慢性症状归因于莱姆病的患者。前瞻性研究2 检查新诊断的莱姆病患者是否患有共病精神障碍 以及基线时相关的认知/行为过程，并跟踪它们 年。我们的目标是确定慢性病发展的危险因素 充分抗生素治疗后出现的莱姆病症状。