THE ROLE OF CO-MORBID MENTAL DISORDERS IN LYME DISEASE

共病精神障碍在莱姆病中的作用

• 批准号: 6862711
• 负责人: Afton L Hassett
• 金额: $ 13.1万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6862711
• 关键词: Lyme disease; behavioral /social science research tag; comorbidity; disease /disorder proneness /risk; human subject; longitudinal human study; mental disorders; pathologic process; patient oriented research; postdoctoral investigator; psychosomatic disorders; questionnaires

DESCRIPTION (provided by investigator): Committed to a career in behavioral science research, the candidate's immediate goals are to obtain high quality didactic training and additional mentored experience related to interdisciplinary research. Long term career goals include exploring the role of co-morbid mental disorders and related psychological processes in rheumatologic illness and eventually becoming an expert on medically unexplained symptom syndromes across specialties. Current research is based on the candidate's stress-diathesis theoretical model for the "psychopathogenesis" of unexplained symptom syndromes present in rheumatology, i.e., Post Lyme Disease and fibromyalgia. The K08 Award would allow the candidate to devote 80 percent of her time to research and training. UMDNJ-Robert Wood Johnson Medical School is an outstanding environment in which to conduct this type of research. In addition to traditional biomedical research, many faculty members are actively exploring the role of psychological processes in health and illness. Mentorship would be provided by two such exceptional faculty, Javier I. Escobar, MD, Chairman of Psychiatry and Leonard H. Sigal MD, Chief of Rheumatology and Director of the Lyme Disease Center at UMDNJ-RWJMS. In addition to superior mentored clinical research experience, the candidate will receive advanced training in research methodology, statistical analysis, the responsible conduct of research, and neuroscience. Training highlights include statistical analyses through the Department of Statistics at Rutgers University and Neuroscience coursework at Princeton University. Mentored experience in research will consist of two studies. Study 1 will assess the co-morbid clinical disorders (Axis I) and pathological personality traits (Axis II) of patients who attribute chronic symptoms to Lyme disease. Study 2 prospectively examines newly diagnosed Lyme disease patients for co-morbid mental disorders and related cognitive/behavioral processes at baseline and follows them for one year. Our goal is to identify risk factors for the development of chronic symptoms ascribed to Lyme disease after adequate antibiotic treatment.

描述（由研究者提供）：致力于行为医学领域的职业生涯 科学研究，候选人的直接目标是获得高质量的 教学培训和额外的指导经验， 跨学科研究长期职业目标包括探索角色 共病精神障碍和相关的心理过程， 风湿病，并最终成为医学专家 各专科的不明原因症状综合征目前的研究基于 考生的压力素质理论模型的“心理病理” 风湿病学中存在的不明原因的症状综合征，即，波斯特莱姆 疾病和纤维肌痛。K 08奖将允许候选人投入80 %的时间用于研究和培训。UMDNJ-Robert Wood约翰逊医疗 学校是一个优秀的环境，在其中进行这种类型的研究。 除了传统的生物医学研究外，许多教职员工都是 积极探索心理过程在健康和疾病中的作用。 导师将由两位如此杰出的教师提供，哈维尔一世。 埃斯科瓦尔，医学博士，精神病学主席和伦纳德H。Sigal医学博士， 他是UMDNJ-RWJMS莱姆病中心的流变学和主任。在 除了上级指导临床研究经验，候选人将 接受研究方法、统计分析、 负责任的研究行为和神经科学。培训亮点包括 罗格斯大学统计系的统计分析 以及普林斯顿大学的神经科学课程辅导经验， 研究将包括两项研究。研究1将评估合并症 临床障碍（轴I）和病理人格特征（轴II） 将慢性症状归因于莱姆病的患者。研究2前瞻性 检查新诊断的莱姆病患者是否有精神障碍 和相关的认知/行为过程，并跟踪他们一个 年我们的目标是确定慢性疾病发展的危险因素， 经过充分的抗生素治疗后出现的莱姆病症状。