Screening for Addiction Risk in Chronic Opioid Therapy

描述(由研究人员提供)：这个第一阶段的应用程序旨在开发阿片成瘾潜力(Soap)的筛选器，这是一种自我给药的简短筛查工具，适用于考虑接受阿片类药物治疗的慢性疼痛患者。肥皂将识别可能有成瘾风险的个人。目前还不存在用于此目的的有效程序。严格的方法论方法将建立可靠性和预测效度阶段I开始测试开发过程。概念图程序将整合疼痛和成瘾专家、提供者和患者的输入，以创建慢性疼痛患者成瘾的可操作性定义。概念图也被用来生成项目并对其进行概念评估。使用横断面方法的初步经验可行性测试将导致肥皂的测试版在第二阶段进行前瞻性验证和交叉验证。将特别注意确保该措施对有成瘾史的慢性疼痛患者的有效性。截止分数的敏感性和特异性将根据测试前的成瘾概率进行计算和检查。Endo制药公司已经实施了实质性的Ill支持阶段。由此产生的测量应该是可靠的、有效的，并且易于在实践环境中使用。

DESCRIPTION (provided by investigator): This Phase I application aims to develop the Screener for Opioid Addiction Potential (SOAP), a self-administered, brief screening tool for chronic pain patients considered for opioid therapy. The SOAP will identify individuals who may be at risk for addiction. No current, validated procedure exists for this purpose. A rigorous, methodological approach will establish reliability and predictive validity Phase I begins the test development process. Concept mapping procedures will integrate input from experts on pain and addiction, providers, and patients to create an operational definition of addiction in chronic pain patients. Concept mapping is also employed to generate items and subject them to a conceptual evaluation. An initial empirical feasibility test, using cross sectional methods, will result in a beta version of the SOAP to be prospectively validated and cross-validated in Phase II. Special attention will be paid to ensure validity of the measure for chronic pain patients with addiction histories. Sensitivity and specificity of cutoff scores will be calculated and examined with respect to pre-test probabilities of addiction Substantial Phase Ill support has been committed by Endo Pharmaceuticals. The resulting measure should be reliable, valid, and easy to use in practice settings.