Exposure of Children with Asthma to Household ETS

患有哮喘的儿童接触家庭 ETS

• 批准号: 6620717
• 负责人: FREDERICK Steven WAMBOLDT
• 金额: $ 30.42万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6620717
• 关键词: African American; Hispanic Americans; asthma; behavioral /social science research tag; caucasian American; clinical research; environmental exposure; gender difference; health behavior; human morbidity; human subject; interview; low socioeconomic status; medically underserved population; middle childhood (6-11); nicotine; passive smoking; racial /ethnic difference; tobacco abuse prevention

DESCRIPTION (provided by applicant): Children with asthma are particularly vulnerable to environmental tobacco smoke (ETS). However, despite this special vulnerability to ETS, children with asthma are at least as likely to live in smoking households, as are healthy children. Controversy exists, however, about whether or not the smoking members of households with children with asthma use specific strategies to reduce the harmful effects of their smoking on their children more than the smoking members of households of healthy children. The central aim of this case-control study is to examine whether or not primary school-aged children with asthma from low-income households have lower household ETS exposure than matched control children. Household ETS exposure will be measured by both objective monitoring, specifically passive nicotine dosimeters and child cotinine assays (the primary hypothesis), and maternal-report (the secondary hypothesis). Ninety children with physician diagnosed asthma and smoking mothers will be matched by age, gender, race/ethnicity, and other relevant variables to 90 healthy children. All children will be recruited from Metro Denver clinics providing services to low-income, underserved populations. The sample will contain equal numbers of African Americans, Hispanics, and Whites. Recruitment will target low-income populations due to their increased prevalence of, and associated morbidity from both asthma and tobacco smoking. We will also examine how specific household smoking behaviors, as reported by mothers, are associated with household nicotine and child cotinine levels. Finally, we have included a set of carefully chosen measures that will be examined in tertiary, exploratory analyses to help understand, clarify, and contextualize the observed results. This study has been carefully designed to correct the serious methodological problems of the prior work in this area. Accordingly, the proposed study will be able to resolve a number of extremely important child health questions of major theoretical and practical importance: (1) do children with asthma have less household ETS exposure as measured by objective monitoring than healthy children; (2) do alterations in household smoking behavior account for this difference; and if so, (3) which specific strategies are effective in reducing children's ETS exposure and which are not? Knowing the answers to these questions, as well as whether there is significant racial/ethnic variability in the answers, will be invaluable to ongoing tobacco intervention and control efforts in families of children with asthma, as well as other vulnerable populations.

描述（由申请人提供）：患有哮喘的儿童尤其容易 容易受到环境烟草烟雾 (ETS) 的影响。然而，尽管有这样的特殊 易受 ETS 影响，患有哮喘的儿童至少有可能生活在 吸烟的家庭，健康的儿童也是如此。然而，存在争议 有哮喘儿童的家庭吸烟成员是否使用 减少吸烟对他们的有害影响的具体策略 家庭中吸烟的儿童数量多于健康儿童。这 这项病例对照研究的中心目的是检查是否原发性 来自低收入家庭的患有哮喘的学龄儿童的患病率较低 家庭 ETS 暴露高于匹配对照儿童。家庭碳排放交易体系暴露 将通过客观监测来测量，特别是被动尼古丁 剂量计和儿童可替宁测定（主要假设），以及 母亲报告（次要假设）。九十名儿童与医生 诊断出的哮喘和吸烟母亲将按年龄、性别、 90 名健康儿童的种族/民族和其他相关变量。全部 儿童将从丹佛都会区诊所招募，为以下人士提供服务： 低收入、服务不足的人群。样本将包含相同数量的 非裔美国人、西班牙裔和白人。招聘将针对低收入人群 人群由于其患病率和相关发病率的增加 哮喘和吸烟。我们还将研究具体家庭如何 据母亲报告，吸烟行为与家庭环境有关 尼古丁和儿童可替宁水平。最后，我们还包括了一组 精心挑选的措施将在第三级、探索性研究中进行审查 分析以帮助理解、澄清观察到的结果并将其置于背景中。 这项研究经过精心设计，旨在纠正严重的方法论问题 该领域前期工作存在的问题。因此，拟议的研究将 能够解决一些极其重要的儿童健康问题 主要理论和实践意义：（1）哮喘儿童是否有 通过客观监测测得的家庭 ETS 暴露量低于健康人群的暴露量 孩子们; (2) 家庭吸烟行为的改变是否可以解释这一点 不同之处;如果是这样，（3）哪些具体策略可以有效减少 儿童的ETS暴露又有哪些不是？知道这些问题的答案 问题，以及是否存在显着的种族/民族差异 答案对于持续的烟草干预和控制非常宝贵 为患有哮喘的儿童以及其他弱势儿童的家庭所做的努力 人口。