BENZODIAZEPINE USE AND RISK OF DISABILITY IN THE ELDERLY

老年人使用苯二氮卓类药物和残疾风险

基本信息

批准号：
6626426
负责人：
SHELLY L GRAY
金额：
$ 10.08万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-01-15 至 2004-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6626426
关键词：
aging benzodiazepines disabling disease disease /disorder proneness /risk drug adverse effect epidemiology functional ability geriatrics health care service utilization human data human old age (65+) longitudinal human study meta analysis outcomes research

项目摘要

DESCRIPTION (Adapted from applicant's abstract): The applicant states that her long-term career goal is to become an independent investigator, focusing on the adverse health outcomes of medication use in the elderly, by utilizing principles of pharmacoepidemology. She currently holds the rank of Assistant Professor in the School of Pharmacy at the applicant institution. She has completed a 2-year research pharmacy fellowship in geriatrics, has conducted research in the area of adverse drug effects in the elderly, and provides clinical services as part of geriatric team. To meet her career objectives, she is proposing to merg her clinical pharmacy background with expertise in epidemiologic methods over a 5-year period by: 1) completing course-work towards a master's degree in the School of Public and Community Health, University of Washington; and 2) conducting supervised research under the guidance of her sponser (David Buchner and co-sponsers (Andreas Stergachis and Andrea LaCroix) Some adverse health consequences of benzodiazepine use in elderly are established and represent a significant public health concern. Yet, according to the applicant, little is known about whether these agents contribute to the disability process. During the proposed award, the applicant plans to determine if benzodiazepine use is associated with the losss of mobility, loss of independence in activities of daily living (ADLs), use of health services, and mortality over a 3- year study period in community dwelling elderly. This research will use data from four large, federally-funded, population-based logitudinal studies of the elderly, containg data on approximately 17,000 individuals. Use of the following data sets is proposed: Established Populations for Epidemiologic Studies of the Elderly; Women's Health and Aging Study; Cardiovascular Health Study; and Group Health Cooperative Demonstration Project. The four outcomes will be evaluated within each dataset, and the data will be poooled for a meta-analysis. Beginning in the third year of the proposed award period, the applicant plans to submit additional competitive grants, and initiate research in other areas related to medication use and adverse health outcomes in the elderly, working closely with her sponsors.

描述（根据申请人的摘要改编）：申请人指出她的长期职业目标是成为一名独立调查员，专注于药物使用的不利健康结果老年人，利用药物血统的原理。她目前在药学院担任助理教授的职级申请人机构。她已经完成了为期2年的研究药房老年医学研究金已经在不利领域进行了研究老年人的药物影响，并提供临床服务作为老年团队。为了实现她的职业目标，她正在建议梅尔她的临床药房背景具有流行病学方法的专业知识在5年的时间内：1）完成硕士的课程工作大学公立和社区卫生学院学位华盛顿； 2）根据她的赞助商（David Buchner和共同发起人（Andreas Stergachis和 Andrea Lacroix）苯二氮卓在老年人中使用的某些不良健康后果是建立并代表了一个重大的公共卫生问题。然而，根据申请人的说法，这些代理人是否了解有助于残疾过程。在拟议的奖励期间，申请人计划确定苯二氮卓的使用是否与流动性损失，每日活动中失去独立性的丧失生活（ADL），卫生服务的使用和死亡率3年社区居住的老年人学习期。这项研究将使用数据来自四个大型，联邦资助的基于人群的逻辑研究在老年人中，约有17,000名个人遏制数据。使用提出以下数据集：已建立的人群老年人的流行病学研究；妇女的健康和衰老研究；心血管健康研究；和团体健康合作示范项目。这四个结果将在每个数据集中评估，并且数据将用于荟萃分析。从第三拟议奖励期的年份，申请人计划提交额外的竞争赠款，并在其他领域启动研究与老年人的药物使用和不良健康结果有关与她的赞助商紧密合作。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Is the use of benzodiazepines associated with incident disability?

DOI：
10.1046/j.1532-5415.2002.50254.x
发表时间：
2002-06-01
期刊：
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
影响因子：
6.3
作者：
Gray, SL;LaCroix, AZ;Buchner, D
通讯作者：
Buchner, D

Physical inactivity and smoking increase risk for serious infections in older women.

缺乏身体活动和吸烟会增加老年女性严重感染的风险。

DOI：
10.1111/j.1532-5415.2000.tb03867.x
发表时间：
2000
期刊：
Journal of the American Geriatrics Society
影响因子：
6.3
作者：
Leveille,SG;Gray,S;LaCroix,AZ;Ferrucci,L;Black,DJ;Guralnik,JM
通讯作者：
Guralnik,JM

Risks for frequent antimicrobial-treated infections in postmenopausal women.

绝经后妇女频繁接受抗菌药物治疗感染的风险。

DOI：
10.1007/bf03324474
发表时间：
2003
期刊：
Aging clinical and experimental research
影响因子：
4
作者：
Boudreau,DeniseM;Leveille,SuzanneG;Gray,ShellyL;Black,DouglasJ;Guralnik,JackM;Ferrucci,Luigi;LaCroix,AndreaZ
通讯作者：
LaCroix,AndreaZ

Can clinical pharmacy services have a positive impact on drug-related problems and health outcomes in community-based older adults?