课题基金 / 基金详情

Reducing CNS-active Medications to Prevent Falls and Injuries in Older Adults

Reducing CNS-active Medications to Prevent Falls and Injuries in Older Adults
减少中枢神经系统活性药物以预防老年人跌倒和受伤
批准号:
10335732
负责人:
SHELLY L GRAY
金额:
$70.76万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-30 至 2022-09-29

项目摘要

项目成果

SHELLY L GRAY的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结
英文摘要
PROJECT SUMMARY Falls are the leading cause of fatal and non-fatal injuries among adults aged 65 and older. Medications that affect the central nervous system (i.e., CNS-active medications) are a key modifiable risk factor for falls, and national guidelines offer clear guidance on medications to avoid for those at risk of falls. However, healthcare provider and patient awareness of medications linked to falls is low, and to date the role of pharmacists in facilitating medication review and reduction to prevent falls has been limited. New approaches to increase uptake of recommendations are thus greatly needed. A multifaceted approach is often essential to successfully taper and discontinue certain CNS-active medications, such as benzodiazepines and opioids. The objective of STOP-FALLS is to implement and evaluate a team-based intervention involving pharmacists, primary care providers, and patients to reduce exposure to CNS-active medications that increase the risk of older adult falls and unintentional injuries. Central to our intervention is direct-to patient education and ongoing provider education and support. The aims are to: 1) ADAPT AND PILOT-TEST approaches necessary for adoption and implementation of evidence-based medication reduction strategies for use in an integrated health care system; 2) IMPLEMENT AND EVALUATE the intervention using an observational cohort design; and 3) ASSESS barriers and facilitators to intervention adoption, implementation and maintenance: clinical leadership influences, intervention adaptability, and implementation costs. Our intervention cohort will consist of older adults who are taking one or more CNS- active medications after the start of intervention implementation by the health system. We will compare this group with a recent historical comparison cohort from the same health plan using the same eligibility criteria for whom we have comparable data on demographics, medical and medication history, and outcomes. The primary outcome will be medically treated falls at 24 months. Secondary outcomes will be unintentional overdose, injuries due to motor vehicle crashes, and direct medical costs of the intervention. Our application is significant because pragmatic approaches to curtail unnecessary CNS- active medication use, by discontinuation of current use and preventing future use, will greatly enhance the capability of health systems to implement population-based fall and injury prevention. With a rapidly aging population and the devastating effects of unintentional injuries and their associated costs, such approaches are greatly needed. Such models could also improve the quality of prescribing more generally in older adults.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergics
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergics
BENZODIAZEPINE USE AND RISK OF DISABILITY IN THE ELDERLY
  • 批准号:
    6137018
  • 项目类别:
  • 资助金额:
    $9.82万
  • 财政年份:
    1998
  • 负责人:
    SHELLY L GRAY
  • 依托单位:
BENZODIAZEPINE USE AND RISK OF DISABILITY IN THE ELDERLY
  • 批准号:
    6626426
  • 项目类别:
  • 资助金额:
    $10.08万
  • 财政年份:
    1998
  • 负责人:
    SHELLY L GRAY
  • 依托单位:
国内基金
海外基金
IL-17A通过STAT5影响CNS2区域甲基化抑制调节性T细胞功能在银屑病发病中的作用和机制研究
miR-20a通过调控CD4+T细胞焦亡促进CNS炎性脱髓鞘疾病的发生及机制研究
  • 批准号:
    --
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2022
  • 负责人:
    王亦舒
  • 依托单位:
血浆CNS来源外泌体中寡聚磷酸化α-synuclein对PD病程的提示研究
  • 批准号:
    82101506
  • 项目类别:
    青年科学基金项目(C类)
  • 资助金额:
    30.0万元
  • 批准年份:
    2021
  • 负责人:
    徐妍
  • 依托单位:
基于脑微血管内皮细胞模型的毒力岛4在单增李斯特菌CNS炎症中的作用及机制研究
  • 批准号:
    32160834
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    35万元
  • 批准年份:
    2021
  • 负责人:
    马勋
  • 依托单位: