HUC BIOMEDICAL RESEARCH IMPROVEMENT PROGRAM

HUC 生物医学研究改进计划

• 批准号: 6518785
• 负责人: ANTONIO E ALEGRIA
• 金额: $ 64.68万
• 依托单位: UNIVERSITY OF PUERTO RICO AT HUMACAO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6518785
• 关键词: minority institution research support

The HUC Biomedical Research Improvement Program has been created with the purpose of providing the means by which faculty members at the Humacao University College will enter into the main stream of biomedical research. At the same time, student participants are involved in research projects which stimulate and better qualify for biomedical graduate students. This application for continuation involves five subprojects; four are from the Chemistry area, and one from the Physics department. One subproject will determine the thermodynamic parameters controlling the stability of the semiquinones interacting with model biological systems and will determine how the rates of formation of oxygen and nitric oxide in redox and ultrasound systems relates to environmental/semiquinone physical properties with the aim of understanding the cytotoxic activity of antitumor quinone containing drugs. Another subproject design new methodologies for the enantioselective synthesis for enantiopure compounds with biological activity which will avoid the production of racemic mixtures which have potential toxic effects in pharmaceutic products due to the presence of the toxic enantiomer. A third Chemistry subproject is aimed at improving the synthetic scope afforded by enzymatic catalysis in organic solvents for asymmetric transformation leading to biomedical relevant compounds. Another Chemistry subproject will measure the molecular/photophysical properties of a selected group of tricyclic neuroleptics with the aim of understanding the allergical and photosensitization occurring as side effects in patients using these drugs. The physics subproject will study the heating and image non- uniformity problems in imaging the brain at high magnetic fields using computer models in order to understand the effects of heating and poor image quality and obtained when high field strengths are used. Undergraduate students will participate in these subprojects. They are trained in different laboratories, spectroscopic and computation techniques as applied to biomedical research. It is expected that the development of this project will serve as a means to obtain the desired goals, i.e., faculty obtaining biomedical mainstream research support and students entering, graduating from graduate, medical or odontology schools and following a biomedical research career.

HUC生物医学研究改进计划已经创建， 目的是提供手段，使教师在 Humacao大学学院将进入生物医学的主流 research.与此同时，学生参与了 刺激生物医学并更好地获得生物医学资格的研究项目 研究生。 这项继续进行的申请涉及五个次级项目，其中四个是 一个来自化学系，一个来自物理系一 该子项目将确定热力学参数控制 半醌类与模拟生物系统相互作用的稳定性 并将决定氧气和一氧化氮的形成率 涉及环境/半醌 物理性质，目的是了解细胞毒活性 抗肿瘤的醌类药物。另一个子项目设计new 对映体纯的对映体选择性合成方法 具有生物活性的化合物，其将避免产生 在制药中具有潜在毒性作用的外消旋混合物 由于有毒对映体的存在，第三化学 分项目的目的是改善综合范围提供的 用于不对称转化的有机溶剂中的酶催化 从而产生生物医学相关化合物。另一个化学子项目 将测量所选基团的分子/物理性质 三环类抗精神病药的目的是了解过敏性 以及在使用这些药物的患者中作为副作用发生的光敏化 毒品物理子项目将研究加热和图像非- 在高磁场下对大脑成像的均匀性问题 计算机模型，以了解加热和穷人的影响 图像质量，并在使用高场强时获得。 本科生将参与这些子项目。他们是 在不同的实验室，光谱和计算培训 技术应用于生物医学研究。预计该 该项目的发展将作为一种手段，以获得所需的 目标，即，教师获得生物医学主流研究支持 以及即将从研究生院、医学院或牙科学院 学校和以下生物医学研究生涯。