OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY

使用光学相干断层扫描进行光学活检

• 批准号: 6647187
• 负责人: JAMES G FUJIMOTO
• 金额: $ 25.59万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-05 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647187
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; diagnosis design /evaluation; disease /disorder model; early diagnosis; fiber optic microscopy; hamsters; human subject; imaging /visualization /scanning; neoplasm /cancer diagnosis; tomography

DESCRIPTION (Adapted from Applicant's Abstract): This is a multidisciplinary collaborative program involving researchers at the Massachusetts Institute of Technology, Harvard Medical School, Massachusetts General Hospital, Brigham and Women's Hospital, and the National Cancer Institute. The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," the real time, in vivo differentiation and monitoring of early neoplastic changes. This program integrates the development of new technology with its application to fundamental and clinical studies in oncology. The applicants propose to: 1. Develop ultrahigh resolution, spectroscopic, and Doppler OCT technology which extends the current 10-15 (m image resolution to the 1-2 (m level. This is a quantum leap in performance which will significantly improve imaging of architectural morphology and facilitate imaging of cellular features for identifying early neoplastic changes. Spectroscopic and Doppler OCT could enable functional imaging of tissue on a micron scale. 2. Develop delivery instruments for OCT which allow noninvasive or minimally invasive clinical imaging. These include a catheter/endoscope, colposcope, hysteroscope, hand held probe, and needle. 3. Investigate OCT imaging of early neoplastic changes and cancer progression in an animal model to define markers of dysplasia and to develop quantitative assessments of vascular density. A noninvasive, real time technique for quantitating angiogenesis can be a powerful research tool for the development of anti-angiogenesis agents. 4. Investigate OCT imaging in the female reproductive tract including the cervix and endometrium. The cervix is an excellent in vivo model system to establish markers of dysplastic change. Hysteroscopic OCT imaging of the uterus could improve the detection of endometrial dysplasia and cancer. 5. Investigate OCT imaging of dysplasia and leukoplakia of oral mucosa and chemoprevention treatment. Approaches to quantitatively assess response to chemoprevention would be important tools for pharmacological trials. 6. Investigate OCT imaging of the GI tract. Explore the feasibility of OCT for differentiating dysplasia and adenocarcinoma of the esophagus to guide conventional excisional biopsy and reduce false negative rates. Develop OCT as a low cost screening technique for Barrett's esophagus. Taken together, these studies will provide new imaging tools for oncology research and also develop new clinical diagnostic and screening techniques.

描述(改编自申请者摘要)：这是一个多学科的 麻省理工学院研究人员参与的合作项目 哈佛医学院，麻省总医院，布里格姆和 妇女医院和国家癌症研究所。这是一个假设 提出了光学相干层析成像(OCT)这一新兴的生物医学 用于组织微结构原位成像的诊断成像技术 开发并应用于“光学活组织检查”，实时，活体 早期肿瘤变化的鉴别和监测。本节目 将新技术的发展与其应用于 肿瘤学基础和临床研究。申请人建议：1. 开发超高分辨率、光谱和多普勒OCT技术 将当前的10-15(M)图像分辨率扩展到1-2(M)级别。这是一个 性能上的量子飞跃，这将显著改善 建筑形态和便于对细胞特征进行成像 识别早期肿瘤性改变。光谱和多普勒OCT可以 实现微米级组织的功能成像。2.发展交付 允许无创或微创临床使用的OCT仪器 成像。包括导尿管/内窥镜、镜、宫内镜、手 拿着探头和针。3.探讨早期肿瘤性改变的OCT成像 和癌症进展的动物模型，以确定不典型增生的标志物和 发展血管密度的定量评估。一种非侵入性的实时 血管生成的量化技术可以成为一种强有力的研究工具 抗血管生成药物的研究进展。4.研究OCT成像技术 女性生殖道，包括宫颈和子宫内膜。宫颈是 一个优秀的体内模型系统，以建立发育异常变化的标记。 宫腔镜下OCT子宫成像可提高对子宫肌瘤的检出 子宫内膜异型增生和癌症。5.探讨异型增生的OCT影像表现。 口腔粘膜白斑及化学预防治疗。实现以下目标的方法 定量评估对化学预防的反应将是 药理试验。6.研究胃肠道的OCT成像。探索 OCT鉴别卵巢上皮异型增生与腺癌的可行性 引导食道常规切除活检减少假阴性 费率。开发OCT作为Barrett‘s食道的低成本筛查技术。 总而言之，这些研究将为肿瘤学提供新的成像工具 研究并开发新的临床诊断和筛查技术。