Obesity and cardiac Risk in American Indian Children

美洲印第安儿童的肥胖和心脏病风险

• 批准号: 6657351
• 负责人: Alexandra K. Adams
• 金额: $ 11.6万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-12 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657351
• 关键词: Native Americans; cardiovascular disorder prevention; cardiovascular disorder risk; child (0-11); clinical research; disease /disorder prevention /control; early experience; family genetics; gene environment interaction; human subject; obesity; patient oriented research

DESCRIPTION (provided by applicant): Background: Childhood obesity is a significant risk factor for the development of adult obesity, cardiovascular disease (CVD), and diabetes. Recent studies suggest very high rates of obesity in American Indian (AI) children. Candidate: This K23 award will facilitate Dr. Alexandra Adams' development as a patient-oriented scientist with a long-term goal of becoming a high-quality, independent academic investigator who develops intervention strategies for prevention of obesity, CVD and diabetes in Al populations. Qualifications: Dr. Adams' unique qualifications for this K23 award include her medical training and a Ph.D. in nutritional science. Since joining the University of Wisconsin (UW) Family Medicine (DFM) clinical and research faculty in 1999, she has established a strong working relationship with Al communities in Wisconsin and has initiated a number of important collaborative studies with tribal communities. Environment: The DFM and Medical School are committed to Dr Adams' development as a patient-oriented scientist. This is reflected in strong support letters, senior research mentors involved with the project, written commitment from her Chair, GCRC support, and collaborative opportunities with other UW research teams in one of the strongest research environments in the US. Training: Dr. Adams will develop her career in patient-oriented research by obtaining advanced training in clinical research design, blostatistics, participatory research, ethics, writing skills, and advanced body composition techniques. As part of her K-23 plan, She will complete the UW Clinical Investigator Preparatory Pathway (CIPP K30 grant) as well as participate in courses, seminars and training activities. She will receive extensive group and one-on-one mentoring from a number of LTW senior NIH-funded scientists and Dr. Ann Macaulay, Director of the Kahnawake Schools Diabetes Prevention Program at McGill University. Research: Dr Adams is working on a three phase collaborative participatory research project with two WI tribal communities who have asked her to partner with them to reduce the disease burden in their communities by decreasing obesity and CVD risk factors in their children. She hypothesizes that the high prevalence of obesity in WI Al children, which places them at high risk for adult CVD and diabetes, begins early in childhood. Thus, obesity prevention efforts must be targeted early in childhood. The project will 1) assess obesity prevalence and cardiac risk factors in Al children ages 0-7, 2) conduct growth modeling of the familial and environmental determinants of obesity, and 3) work in partnership with the communities to design community-based early intervention strategies to prevent childhood obesity. Significance: With the assistance of the K23 award, Dr. Adams will develop and test interventions to prevent obesity in Al children and its sequelae; CVD and diabetes.

描述（由申请人提供）： 背景：儿童肥胖是成人肥胖发展的重要危险因素， 心血管疾病（CVD）和糖尿病。最近的研究表明美洲印第安人 (AI) 儿童的肥胖率非常高。候选人：该 K23 奖项将促进 Alexandra Adams 博士的 发展成为以患者为中心的科学家，长期目标是成为高素质、 独立的学术研究者，制定预防干预策略 Al 人群中的肥胖、CVD 和糖尿病。资格：亚当斯博士的独特资格 该 K23 奖项包括她的医学培训和博士学位。在营养科学中。自从加入 1999 年，她在威斯康星大学 (UW) 家庭医学 (DFM) 临床和研究系任教，与威斯康星州的阿尔社区建立了牢固的工作关系，并与部落社区启动了多项重要的合作研究。环境：DFM 和 医学院致力于将亚当斯博士培养成为一名以患者为中心的科学家。这是 反映在强有力的支持信中，参与该项目的高级研究导师，书面 主席的承诺、GCRC 的支持以及与威斯康星大学其他部门的合作机会 研究团队处于美国最强大的研究环境之一。培训：亚当斯博士将通过获得临床高级培训来发展她在以患者为导向的研究方面的职业生涯 研究设计、统计统计学、参与性研究、伦理、写作技巧和先进的身体 构图技巧。作为 K-23 计划的一部分，她将完成华盛顿大学临床研究员课程 预科课程（CIPP K30 补助金）以及参加课程、研讨会和培训 活动。她将从许多 LTW 那里获得广泛的团体和一对一指导 美国国立卫生研究院 (NIH) 资助的资深科学家和卡纳威克学校校长安·麦考利 (AnnMacaulay) 博士 麦吉尔大学糖尿病预防计划。研究：亚当斯博士正在研究一项三 与两个威斯康星州部落社区进行的阶段合作参与性研究项目 请她与他们合作，通过以下方式减轻社区的疾病负担： 减少儿童肥胖和心血管疾病的危险因素。她推测高 WI Al 儿童肥胖率较高，这使他们面临成人心血管疾病和心血管疾病的高风险 糖尿病，从儿童早期开始。因此，预防肥胖的努力必须尽早确定。 童年。该项目将 1) 评估阿尔茨海默病儿童的肥胖患病率和心脏病危险因素 0-7 岁，2) 对家庭和环境决定因素进行生长建模 肥胖，3) 与社区合作设计基于社区的早期 预防儿童肥胖的干预策略。意义：在K23的协助下 获得该奖项后，亚当斯博士将开发和测试预防阿尔茨海默病儿童肥胖的干预措施 后遗症；心血管疾病和糖尿病。