Temperature-dependent Terahertz Time-Domain Spectroscopy as a Tool to Measure Drug-Polymer Interactions in Polymeric Nanoparticles

温度依赖性太赫兹时域光谱作为测量聚合物纳米颗粒中药物-聚合物相互作用的工具

• 批准号: 2260235
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2260235
• 关键词: Temperature; dependent; Terahertz; Time; Domain

Polymeric nanoparticles are implemented as carriers in the pharmaceutical industry for drug delivery applications due to their high loading capability, biocompatibility and biodegradability. Such systems have demonstrated effective transport of the active ingredient to target sites at improved therapeutic efficacy; with the interaction between polymer and drug key to the design of these nanoparticles. Further work, however, is necessary for an improved understanding of the types and influences of drug-polymer interactions, as well as the optimum procedure to extract this information.Consequently, the aim of this project is to assess the non-destructive and non-invasive terahertz timedomain spectroscopy (THz-TDS) as a tool to measure drug-polymer interactions, in order to optimise the design of polymeric nanoparticles. Typically ranging from 100 GHz to 10 THz, terahertz radiation lies between the infrared and microwave regions of the electromagnetic spectrum. Both intermolecular and intramolecular bond interactions, vibrations and rotations occur in this frequency range; thus, highlighting the potential of this technique to provide crucial insight into the molecular motions and dynamics involved in drug-polymer systems. Fundamentally, the outcome of the project is dependent on three key objectives: to develop an understanding of the underlying principles through literature review and experimental work, to formulate a polymeric nanoparticle and to evaluate the designed polymeric nanoparticle. For analysis and characterisation, THz-TDS - as already stated - will be used in combination with complementary crystallography techniques in a reproducible manner. The proposed investigation aligns to EPSRC's 'Sensors and Instrumentation' and 'Chemical Biology and Biological Chemistry' research areas and constitutes academic and societal worth, as well as practical importance in the pharmaceutical industry. Firstly, through appropriate work and publications, the project would enhance understanding of the fundamental principles surrounding drug-polymer interactions and aid in tackling existing discourse or disagreements in literature. Moreover, by improving understanding of the fundamentals, the practical implications of the research on an industrial scale are significant. A greater idea of the necessary and unnecessary components for formulation would speed up development processes and save costs through an earlier appreciation of what would and wouldn't work. Further exploring the influence of interactions and investigating novel combinations brings the possibility of introducing new medicines - as well those previously failing trial phases - into application. Thus, the benefits to society include enhanced availability of drugs and the treatment of a wider range of diseases, at more affordable prices. The project is funded by and will be carried out in conjunction with collaborators at AstraZeneca.

聚合物纳米颗粒由于其高负载能力、生物相容性和生物降解性而在制药工业中被用作药物递送应用的载体。这种系统已经证明了有效的运输的活性成分的目标网站在改善的治疗效果;与聚合物和药物之间的相互作用的关键设计这些纳米粒子。然而，进一步的工作是必要的，以提高对药物-聚合物相互作用的类型和影响的理解，以及最佳的程序来提取这些信息。因此，本项目的目的是评估非破坏性和非侵入性太赫兹时域光谱（THz-TDS）作为一种工具来测量药物-聚合物相互作用，以优化聚合物纳米粒子的设计。太赫兹辐射通常在100 GHz到10 THz的范围内，位于电磁波谱的红外和微波区域之间。分子间和分子内键的相互作用，振动和旋转都发生在这个频率范围内;因此，突出了这种技术的潜力，以提供关键的洞察药物-聚合物系统中涉及的分子运动和动力学。从根本上说，该项目的成果取决于三个关键目标：通过文献综述和实验工作来理解基本原理，制定聚合物纳米颗粒并评估所设计的聚合物纳米颗粒。对于分析和表征，THz-TDS -如前所述-将以可再现的方式与互补晶体学技术结合使用。拟议的调查符合EPSRC的“传感器和仪器”和“化学生物学和生物化学”研究领域，并构成学术和社会价值，以及在制药行业的实际重要性。首先，通过适当的工作和出版物，该项目将加强对药物-聚合物相互作用基本原理的理解，并有助于解决文献中现有的讨论或分歧。此外，通过提高对基本原理的理解，工业规模研究的实际意义是重大的。更好地了解配方的必要和不必要组成部分将加快开发进程，并通过更早地了解什么可行，什么不可行来节省成本。进一步探索相互作用的影响和研究新的组合带来了引入新药的可能性-以及那些以前失败的试验阶段-进入应用。因此，对社会的惠益包括增加药物供应，以更负担得起的价格治疗更广泛的疾病。该项目由阿斯利康资助，并将与阿斯利康的合作者共同开展。