Safe carbenoid chemistry with sulfoxonium ylides

与亚砜叶立德进行安全的类胡萝卜素化学反应

• 批准号: 2263552
• 金额: --
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2263552
• 关键词: Safe; carbenoid; chemistry; sulfoxonium; ylides

The project will develop the current scope of metal-catalysed reactions of sulfoxonium ylides. Sulfoxonium ylides are safer surrogates to diazo compounds that are to date the most versatile and main source of metal carbenes for the synthesis of organic molecules relevant to the development of pharmaceuticals, agrochemicals and materials. However, the chemistry of sulfoxonium ylides is underdeveloped and we must establish how to improve their reactivity to fulfil their potential in organic synthesis. The project will focus on palladium and nickel-catalysed cross-coupling reactions for the formation of carbon-carbon bonds, following on our recent work published in Org. Lett. 2019, 21, 296-299.

该项目将扩大氧化锍叶立德金属催化反应的现有范围。氧化锍叶立德是重氮化合物的更安全的替代物，重氮化合物是迄今为止用于合成与药物、农用化学品和材料开发相关的有机分子的最通用和主要的金属卡宾来源。然而，氧化锍叶立德的化学是欠发达的，我们必须建立如何提高它们的反应性，以发挥其在有机合成中的潜力。该项目将专注于钯和镍催化的交叉偶联反应，以形成碳-碳键，这是我们最近在Org. Lett上发表的工作。2019，21，296-299.