New Directions in Carbenoid Chemistry

类胡萝卜素化学的新方向

• 批准号: 1213246
• 负责人: Huw Davies
• 金额: $ 39万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213246&HistoricalAwards=false
• 关键词: New; Directions; Carbenoid; Chemistry

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Huw M. Davies of the Department of Chemistry at Emory University will explore the development of new synthetic methods using donor/acceptor carbenoids as the key intermediates. While rhodium catalysts are well established for this type of chemistry, this study will define the new synthetic opportunities that exist when silver and gold are used as catalysts. The project will also expand the range of viable donor groups that can be employed in this chemistry with a particular emphasis on the stereoselective synthesis of novel amino acids. The new synthetic methodologies developed during these studies could become enabling technologies that will impact other fields of science such as pharmaceutical and materials science. The program will contribute to environmentally benign methods for chemical synthesis as the key reactions can be conducted with extremely low catalyst loadings and nitrogen gas is the only by-product. In addition, this project will provide excellent training of students, from pre-undergraduate to post-doctoral, including those from groups historically underrepresented in the sciences.

本课题由化学系化学合成项目资助，Huw M.埃默里大学化学系的戴维斯将探索使用供体/受体卡宾作为关键中间体的新合成方法的发展。虽然铑催化剂是建立这种类型的化学，本研究将定义新的合成机会时，存在的银和金被用作催化剂。该项目还将扩大可用于该化学的可行供体基团的范围，特别强调新型氨基酸的立体选择性合成。 在这些研究中开发的新合成方法可能成为影响其他科学领域的技术，如制药和材料科学。该计划将有助于环境友好的化学合成方法，因为关键反应可以在极低的催化剂负载量下进行，氮气是唯一的副产品。 此外，该项目将为学生提供优秀的培训，从大学预科到博士后，包括那些来自历史上在科学领域代表性不足的群体的学生。