New Advances in Rhodium Carbenoid Chemistry

类胡萝卜素铑化学新进展

• 批准号: 0907936
• 负责人: Huw Davies
• 金额: $ 41.5万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907936&HistoricalAwards=false
• 关键词: New; Advances; Rhodium; Carbenoid; Chemistry

The focus of this research is to develop a practical catalytic method for CH functionalization by means of carbenoid-induced CH insertion. This project covers the design of new chiral catalysts and the application of unusual carbenoid transformations into useful synthetic methods. Studies will also be conducted to further define the scope of rhodium-carbenoid induced CH functionalization with emphasis on refining the controlling elements for regioselective CH functionalization and broadening the range of donor/acceptor carbenoids that can be used in this chemistry.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Huw M.L Davies of the Department of Chemistry at SUNY at Buffalo. Dr. Davies will focus his work on the development of methodologies for metal catalyzed asymmetric transformations. The use of donor/acceptor-substituted carbenoids to increase the scope of C-H insertion chemistry will be highlighted by this research. The project has potential broader impact for the pharmaceutical and fine chemicals industries and the work provides an excellent venue for the training of undergraduates, graduate students and postdoctoral associates.

本研究的重点是开发一种实用的催化方法，通过类卡宾诱导的CH插入CH功能化。 该项目涵盖了新的手性催化剂的设计和不寻常的类卡宾转化为有用的合成方法的应用。 此外，还将开展研究，以进一步确定铑-类卡宾诱导的CH官能化的范围，重点是改进区域选择性CH官能化的控制元素，并扩大可用于该化学的供体/受体类卡宾的范围。有了这个奖项，有机和大分子化学计划将支持纽约州立大学布法罗分校化学系的Huw M.L Davies博士的研究。 Davies博士将专注于金属催化不对称转化方法学的发展。 使用供体/受体取代的类卡宾，以增加C-H插入化学的范围将突出这项研究。 该项目对制药和精细化工行业具有潜在的更广泛的影响，并为本科生，研究生和博士后助理的培训提供了一个很好的场所。