A NETWORK OF RESEARCH UNITS TO STUDY CLINICAL WOUND CARE

研究临床伤口护理的研究单位网络

• 批准号: 6632713
• 负责人: James V. Quinn
• 金额: $ 12.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-07 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6632713
• 关键词: antibiotics; clinical research; clinical trials; emergency care; experimental designs; health care personnel education; health care personnel performance; human subject; human therapy evaluation; longitudinal human study; outcomes research; patient care management; skin infection; trauma; wound healing

DESCRIPTION (Taken from the applicants abstract): Next to the common cold, traumatic wounds are the most common reasons people seek medical care in the United States. An estimated 3.9 billion dollars of charges are incurred yearly to treat simple lacerations alone. Most of our knowledge and recommendations regarding the treatment of wounds is based on old dogma related to basic science research that has little clinical relevance. There is a lack of clinical outcomes research to determine the most efficient method to treat traumatic wounds. The purpose of the proposed application is to develop the candidate into an independent career clinical-outcomes researcher through formal training and practical experience. The training goal of the candidate will be to complete a Masters of Clinical Research (MCR) at the University of California, San Francisco (UCSF). The MCR requires 36 quarter-hours of didactic courses tailored to the candidates needs and publication of an original scientific paper in lieu of a Masters thesis. It involves strong preceptor relationships with faculty mentors. The practical-experience goal will be achieved by completing two scientific projects during the course of the award. Early in the course of the award, the candidate will develop and implement a clinical research unit (CRU) in emergency medicine at UCSF. Through implementing this program to screen, recruit and enroll patients a randomized trial to determine the best way to treat simple hand lacerations will be completed. In this trial conservative management (non-suture closure) will be compared to traditional suture management. The primary outcome will be three month cosmesis and wound healing, with secondary outcomes of pain, time and patient satisfaction also being assessed. In the later years of the award, as the candidate completes his MCR and fully develops his local CRU, he will become a multi-center clinical-trials investigator. This will be accomplished by using his formal training and with the help of his mentor, Dr Cummings, the Director of the University of Califomia Coordinating Center (UCCC). The UCCC is specifically designed to help run multi center clinical trials. With the use of the UCCC resources a trials network utilizing common databases and data collection techniques will be used to undertake a multi-center clinical trial on the use of prophylactic antibiotics for the management of dog bites. In this study amoxicillin/clavulanic acid will be compared to placebo. The primary outcome of the study will be infection. Other outcomes studied will be wound-healing patient satisfaction and cost.

描述（摘自申请人摘要）： 除了普通的感冒，外伤是人们最常见的原因， 在美国寻求医疗服务。据估计， 单是治疗简单的撕裂伤，每年都要收费。我们的大多数 关于伤口治疗的知识和建议是基于旧的 与基础科学研究相关的教条，几乎没有临床意义。 缺乏临床结果研究，以确定最有效的 治疗创伤的方法。建议申请的目的是 发展候选人成为一个独立的职业临床结果研究员 通过正规培训和实践经验。的培养目标 候选人将完成临床研究硕士（MCR）在 加州大学弗朗西斯科分校（UCSF）。MCR要求36 四分之一小时的教学课程适合候选人的需要， 发表原创科学论文代替硕士论文。它 涉及到导师与教师导师之间牢固的关系。的 实践经验的目标将通过完成两个科学的 项目在获奖过程中。在颁奖初期， 候选人将开发和实施一个临床研究单位（CRU）， 加州大学旧金山分校的急诊科通过实施该方案筛选， 招募患者进行随机试验，以确定 治疗简单的手部撕裂伤。在本试验中， 管理（非缝合闭合）将与传统缝合进行比较 管理主要结果将是三个月的美容和伤口愈合， 疼痛、时间和患者满意度的次要结果也被 评估。在该奖项的后期，随着候选人完成MCR， 并充分发展他的当地CRU，他将成为一个多中心的临床试验， 调查员这将通过使用他的正规培训和 在他的导师卡明斯博士的帮助下， 加州协调中心（UCCC）。UCCC是专门为帮助 进行多中心临床试验利用UCCC的资源， 将使用利用共同数据库和数据收集技术的网络 开展多中心临床试验， 抗生素治疗狗咬伤本研究 阿莫西林/克拉维酸将与安慰剂进行比较。的主要结局 研究将是感染。研究的其他结果将是伤口愈合 患者满意度和成本。