CORRELATION ANALYSIS OF SICKLE CELL ANEMIA DATA

镰状细胞性贫血数据的相关性分析

• 批准号: 6653542
• 负责人: FARAMARZ VALAFAR
• 金额: $ 28.8万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653542
• 关键词: biological products; biomedical resource; carbohydrates; immunology; infection; inflammation; international health /scientific organization

These studies are preliminary to synthesizing a variety of furanosides as model compounds for parasite and fungal glycoconjugates that often exhibit non-reducing terminal furanose residues as immunodominant haptens. Simple furanosides can be used in the production and testing of antibodies for serodiagnosis and as substrates for putative glycosyltransferases and glycohydrolases in fungi and parasitic organisms. A method for maximizing the yields of methyl (- and (-hexofuranosides was tested on glucose, mannose, and galactose. So far, five of the six possible furanosides (with the exception of methyl (-glucofuranoside) from these sugars have been synthesized and isolated in pure form. Identities of the products were authenticated by comparison of 1H-NMR spectra at 600 MHz with those published previously. Since the previously published spectra were acquired at 270 MHz, a number of resonances were poorly resolved and/or exhibited non-first-order coupling. Spectra wer e acquired for this work at much higher field (600 MHz), enabling determination of chemical shifts and coupling constants for a number of ring proton resonances not previously reported for these compounds. Work on obtaining methyl (-glucofuranoside in pure form is continuing.

这些研究是合成各种 作为寄生虫和真菌糖缀合物的模型化合物的呋喃糖苷 其通常表现出非还原性末端呋喃糖残基， 免疫显性半抗原。 简单的呋喃糖苷可用于 生产和测试用于血清诊断的抗体， 糖基转移酶和糖水解酶的底物 真菌和寄生生物。 一种用于最大化以下物质的产率的方法， 甲基（-和（-己基呋喃糖苷）对葡萄糖、甘露糖和 半乳糖。 到目前为止，六种可能的呋喃糖苷中有五种（ 这些糖中的甲基（β-呋喃葡糖苷）除外， 合成并以纯形式分离。 产品特性 通过比较600 MHz下的1H-NMR光谱与 那些以前出版的。 由于先前公布的光谱 在270 MHz下采集，许多共振分辨率很差 和/或表现出非一阶耦合。 采集光谱， 这种工作在更高的领域（600兆赫），使确定 环质子数的化学位移和耦合常数 这些化合物以前没有报道过的共振。 工作 继续获得纯形式的甲基β-呋喃葡糖苷。